Evidence map›Paper›PMID 33880542›Full record

ReviewEuropace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology2021

Emerging evidence for a mechanistic link between low-frequency oscillation of ventricular repolarization measured from the electrocardiogram T-wave vector and arrhythmia.

Peter Taggart, Esther Pueyo, Stefan van Duijvenboden, Bradley Porter, Martin Bishop, David A Sampedro-Puente, M Orini, B Hanson, Christopher A Rinaldi, Jaswinder S Gill and 1 more

Open access · hybridAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.8field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Article
  3. Frontiers in pharmacology · 2025
    Article
  4. High-density isochronal repolarization mapping and re-entry vulnerability estimation for scar-related ventricular tachycardia ablation: mechanistic basis, clinical application, and challenges.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2024
    Review
  5. Automatic measurement of short-term variability of repolarization to indicate ventricular arrhythmias in a porcine model of cardiac ischaemia.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2023
    Article
  6. Optimizing patient selection for primary prevention implantable cardioverter-defibrillator implantation: utilizing multimodal machine learning to assess risk of implantable cardioverter-defibrillator non-benefit.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 4 countries.

Peter TaggartDepartment of Cardiovascular Sciences, University College London, London, UK.
Esther PueyoBSICOS Group, 13A, 11S, Aragon, University of Zaragoza, Spain.ORCID 0000-0002-1960-407X
Stefan van DuijvenbodenDepartment of Cardiovascular Sciences, University College London, London, UK.
Bradley PorterDepartment of Imaging Sciences and Biomedical Engineering, KCL, London, UK.
Martin BishopDepartment of Imaging Sciences and Biomedical Engineering, KCL, London, UK.
David A Sampedro-PuenteBSICOS Group, 13A, 11S, Aragon, University of Zaragoza, Spain.
M OriniDepartment of Cardiovascular Sciences, University College London, London, UK.
B HansonUCL Mechanical Engineering, University College London, London, UK.
Christopher A RinaldiCardiology Department, Guys and St Thomas' Hospital, London, UK.
Jaswinder S GillCardiology Department, Guys and St Thomas' Hospital, London, UK.
Pier LambiaseDepartment of Cardiovascular Sciences, University College London, London, UK.ORCID 0000-0002-9055-9267
University College London · GBLaboratoire d’Imagerie Biomédicale · FRSt Thomas' Hospital · GBUniversidad de Zaragoza · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Strong recent clinical evidence links the presence of prominent oscillations of ventricular repolarization in the low-frequency range (0.04-0.15 Hz) to the incidence of ventricular arrhythmia and sudden death in post-MI patients and patients with ischaemic and non-ischaemic cardiomyopathy. It has been proposed that these oscillations reflect oscillations of ventricular action potential duration at the sympathetic nerve frequency. Here we review emerging evidence to support that contention and provide insight into possible underlying mechanisms for this association.

Indexed as

Arrhythmias, CardiacMyocardial InfarctionAction PotentialsElectrocardiographyHeart VentriclesHumansAction potential durationArrhythmiaBeta-adrenergic stimulationElectrophysiologyLow-frequency oscillationsMechano-electric feedbackRepolarizationT wave

Identifiers

PMID33880542
PMCPMC8427352
OpenAlexW3156614675

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.