Evidence map›Paper›PMID 33880435›Full record

ArticleACS applied bio materials2020

Supramolecular assembly of Toll-like receptor 7/8 agonist into multimeric water-soluble constructs enables superior immune stimulation

Alexander K Andrianov, Alexander Marin, Ruixue Wang, Hatice Karauzum, Ananda Chowdhury, Pragati Agnihotri, Abdul S Yunus, Roy A Mariuzza, Thomas R Fuerst

Open access · greenAbstract read
In one paragraph

Article in ACS applied bio materials, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 33 citations in OpenAlex.

  1. Article
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  9. Article
  10. Review
  11. Cyclo- and Polyphosphazenes for Biomedical Applications.Molecules (Basel, Switzerland) · 2022
    Review
  12. Article
  13. Article
  14. Article
  15. Article
  16. Review
  17. Review
  18. Article
  19. Molecular pharmaceutics · 2021
    Article
  20. Design of a native-like secreted form of the hepatitis C virus E1E2 heterodimer.Proceedings of the National Academy of Sciences of the United States of America · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Alexander K AndrianovInstitute for Bioscience and Biotechnology Research, University of Maryland, Rockville, Maryland, 20850, USA.
Alexander MarinInstitute for Bioscience and Biotechnology Research, University of Maryland, Rockville, Maryland, 20850, USA.
Ruixue WangInstitute for Bioscience and Biotechnology Research, University of Maryland, Rockville, Maryland, 20850, USA.
Hatice KarauzumIntegrated BioTherapeutics, Inc., Rockville, MD 20850, USA.
Ananda ChowdhuryInstitute for Bioscience and Biotechnology Research, University of Maryland, Rockville, Maryland, 20850, USA.
Pragati AgnihotriDepartment of Cell Biology and Molecular Genetics, University of Maryland, College Park, Maryland, 20742, USA.
Abdul S YunusInstitute for Bioscience and Biotechnology Research, University of Maryland, Rockville, Maryland, 20850, USA.
Roy A MariuzzaInstitute for Bioscience and Biotechnology Research, University of Maryland, Rockville, Maryland, 20850, USA.
Thomas R FuerstInstitute for Bioscience and Biotechnology Research, University of Maryland, Rockville, Maryland, 20850, USA.
Advanced Bioscience Laboratories (United States) · USIntegrated BioTherapeutics (United States) · US

Funding

Structure-Based Vaccine Design for Hepatits C VirusR01AI132213 · NIAID · UNIV OF MARYLAND, COLLEGE PARK · PI ANDRIANOV, ALEXANDER, FOUNG, STEVEN · 2017 to 2021
$6.0M
NIAID NIH HHS R01 AI132213
6 · The paper itself

Abstract

Resiquimod or R848 (RSQD) is a Toll-like receptor (TLR) 7/8 agonist which shows promise as vaccine adjuvant due to its potential to promote highly desirable cellular immunity. The development of this small molecule in the field to date has been largely impeded by its rapid

Indexed as

Hepatitis C virusImmunoadjuvantsMultimericSupramolecular chemistryTLR agonistsVaccine delivery

Identifiers

PMID33880435
PMCPMC8054952
OpenAlexW3015840890

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.