Evidence map›Paper›PMID 33880333›Full record

ArticleTranslational pediatrics2021

Prenatal, perinatal, and postnatal factors associated with autism spectrum disorder cases in Xuzhou, China.

Zenghua Yong, Yunlong Dou, Yuchen Gao, Xuena Xu, Yanli Xiao, Hongjuan Zhu, Shengli Li, Baoqiang Yuan

Open access · diamondAbstract read
In one paragraph

Article in Translational pediatrics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
1.7field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it, 22 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Zenghua YongChildren's Neurological Rehabilitation Center, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, China.
Yunlong DouChildren's Neurological Rehabilitation Center, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, China.
Yuchen GaoChildren's Neurological Rehabilitation Center, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, China.
Xuena XuChildren's Neurological Rehabilitation Center, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, China.
Yanli XiaoChildren's Neurological Rehabilitation Center, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, China.
Hongjuan ZhuChildren's Neurological Rehabilitation Center, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, China.
Shengli LiDepartment of Medical Records, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, China.
Baoqiang YuanChildren's Neurological Rehabilitation Center, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, China.
Xuzhou Medical College · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe aim of the present study was to explore the prenatal, perinatal, and postnatal risk factors in children with autism spectrum disorder (ASD) from Xuzhou, China by comparing them with healthy children.

methodsChildren with ASD who received rehabilitation training at special education schools and rehabilitation institutions in Xuzhou were selected as the ASD group, and healthy children during the same period were selected as the healthy non-ASD group. A questionnaire based on the possible causes and susceptibility factors of ASD in children was issued and given to all children in this study.

resultsThe findings of the present study revealed a higher prevalence of prenatal, perinatal, and postnatal factors in children with ASD compared with healthy children. There were significantly more males than females in the ASD group, and the proportion of boys to girls was 5.81:1 (P<0.05). Logistic regression analysis suggested that the risk factors of male children developing ASD were feeding difficulties, poor living environment during pregnancy, maternal exposure to cigarette smoking during pregnancy, and perinatal hypoxia. Factors associated with ASD risk among were identified, such as living environment during pregnancy, delivery method, feeding difficulties, and epilepsy (P<0.05). Feeding difficulties and living in the countryside during pregnancy might be risk factors for ASD in girls according to the logistic regression analysis.

conclusionsThis survey confirmed the high prevalence of prenatal, perinatal, and postnatal factors in children with ASD. Some of these factors may be effective entry points for the prevention and treatment of ASD.

Indexed as

Autism spectrum disorders (ASDs)occupational therapyperinatalpostnatalprenatal

Identifiers

PMID33880333
PMCPMC8041613
OpenAlexW3138164333

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.