Evidence map›Paper›PMID 33880120›Full record

ReviewJournal of oncology2021

The Potential of circRNA as a Novel Diagnostic Biomarker in Cervical Cancer.

Shuying Chen, Xiaoyi Yang, Chengxuan Yu, Wenhan Zhou, Qiuyi Xia, Ying Liu, Qiudan Chen, Xiaotong Chen, Yuan Lv, Yong Lin

Open access · hybridAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of oncology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 1 pooled it
2.3field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 1 synthesis or guideline pooled it, 33 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Shuying ChenDepartment of Laboratory Medicine, Huashan Hospital, Fudan University, Shanghai 200040, China.
Xiaoyi YangSchool of Medicine, Shanghai Jiao Tong University, Shanghai 200025, China.
Chengxuan YuSchool of Medicine, Shanghai Jiao Tong University, Shanghai 200025, China.
Wenhan ZhouShanghai Medical College, Fudan University, Shanghai 200032, China.
Qiuyi XiaShanghai University of Medicine & Health Sciences, Shanghai 200237, China.
Ying LiuShanghai Medical College, Fudan University, Shanghai 200032, China.
Qiudan ChenDepartment of Central Laboratory, Clnical Laboratory, Jingan District Central Hospital, Fudan University, Shanghai 200040, China.
Xiaotong ChenDepartment of Laboratory Medicine, Huashan Hospital, Fudan University, Shanghai 200040, China.
Yuan LvDepartment of Laboratory Medicine, Huashan Hospital, Fudan University, Shanghai 200040, China.ORCID https://orcid.org/0000-0003-3487-2651
Yong LinDepartment of Laboratory Medicine, Huashan Hospital, Fudan University, Shanghai 200040, China.ORCID https://orcid.org/0000-0003-3938-9765
Fudan University · CNShanghai Jiao Tong University · CNShanghai Medical College of Fudan University · CNShanghai University of Medicine and Health Sciences · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cervical cancer is the fourth most common cancer among females worldwide. In spite of advances in detection and treatment, it is still one of the most dangerous gynecological malignancies in the world, especially in developing countries, and seriously threatens human health. Circular RNA (circRNA) is a special new type of endogenous noncoding RNA discovered recently. They form a covalently closed continuous loop and are specifically expressed in the eukaryotic transcriptome. With further understanding of circular RNA, a large number of studies have determined the key regulatory role of circRNA in a variety of diseases, especially cancer (including cervical cancer, liver cancer, and lung cancer). In addition, it has also been found that the abnormal expression of circRNA is related to its pathological characteristics in cervical cancer tissue, which can be used as a potential indicator for early screening and diagnosis of cervical cancer, targeted therapy, and prognosis prediction. This article summarizes the recent research achievements of circRNAs in cervical cancer. We briefly described the abnormal expression of circRNA in cervical cancer and discussed the involvement of circRNA in the occurrence process of cervical cancer by regulating cell proliferation, migration, invasion, and apoptosis. We believe that circRNA has potential value as a biomarker in the diagnosis and prognosis of cervical cancer.

Identifiers

PMID33880120
PMCPMC8046565
OpenAlexW3141772089

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.