ReviewInternational journal of general medicine2021
A Narrative Review of Gut-Muscle Axis and Sarcopenia: The Potential Role of Gut Microbiota.
Review in International journal of general medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
60 citing papers in PubMed, 1 synthesis or guideline pooled it, 80 citations in OpenAlex.
- Gut microbiome changes due to sleep disruption in older and younger individuals: a case for sarcopenia?Sleep · 2022Pooled it
- Trial
- Preliminary clinical study on the synergistic effects of prebiotics and β-hydroxy-β-methylbutyrate in improving muscle function and intestinal barrier function in elderly patients with sarcopenia.Aging clinical and experimental research · 2026Trial
- The promising effects of a multi-species synbiotic preparation on metabolic profile in elderly patients with type 2 diabetes and high cardiovascular risk: a randomized, triple-blind, placebo-controlled trial.Nutrition & diabetes · 2025Trial
- A clinical trial about effects of prebiotic and probiotic supplementation on weight loss, psychological profile and metabolic parameters in obese subjects.Endocrinology, diabetes & metabolism · 2023Trial
- Fermented protein foods as modulators of the gut-muscle axis: mechanisms, evidence, and future directions.Communications biology · 2026Review
- Association of composite inflammatory indicators with osteoporosis and sarcopenia in type 2 diabetes mellitus: the mediating role of inflammation.Journal of endocrinological investigation · 2026Article
- Microbiota and Nutritional Changes Following a Low-FODMAP Diet in Patients with Ulcerative Colitis and Irritable Bowel Syndrome: A Randomized Controlled Trial.Microorganisms · 2026Article
- Baseline Oral Microbiota Richness Is Associated with Training-Induced Improvements in Relative Handgrip Strength in Older Adults.Nutrients · 2026Article
- The Gut-Muscle Axis in Sarcopenia: Mechanisms, Evidence Gaps and Translational Challenges.Biomedicines · 2026Review
- Postbiotics and Skeletal Muscle Health: Molecular Mechanisms and Translational Perspectives.International journal of molecular sciences · 2026Review
- Article
- An integrated drug repositioning analysis identifies rosiglitazone as a treatment for sarcopenia.Communications biology · 2026Article
- Sarcopenia in patients with active ulcerative colitis: associations with serum metabolites and gut microbiota.Frontiers in nutrition · 2026Article
- Association between a dietary index for gut microbiota and frailty in U.S. adults aged 40 and older: evidence from NHANES 1999-2018.Journal of health, population, and nutrition · 2025Article
- Gut microbiota-mediated betaine regulates skeletal muscle fiber type transition by affecting mGut microbes · 2025Article
- Archaea methanogens are associated with cognitive performance through the shaping of gut microbiota, butyrate and histidine metabolism.Gut microbes · 2025Article
- Can Dietary Supplements Support Muscle Function and Physical Activity? A Narrative Review.Nutrients · 2025Review
- Article
- Prevalence of Traditional East Asian Medicine Patterns among Older Adults with Sarcopenia: a systematic review of observational studies.Journal of pharmacopuncture · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Sarcopenia is a multifactorial disease related to aging, chronic inflammation, insufficient nutrition, and physical inactivity. Previous studies have suggested that there is a relationship between sarcopenia and gut microbiota,namely, the gut-muscle axis. The present review highlights that the gut microbiota can affect muscle mass and muscle function from inflammation and immunity,substance and energy metabolism, endocrine and insulin sensitivity, etc., directly or indirectly establishing a connection with sarcopenia, thereby realizing the "gut-muscle axis".
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.