Observational studyClinical interventions in aging2021
Impact of Frailty on the Risk of Exacerbations and All-Cause Mortality in Elderly Patients with Stable Chronic Obstructive Pulmonary Disease.
Observational study in Clinical interventions in aging, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05922202 (Influence of Frailty on Cardiovascular Events and Mortality in Patients With Chronic Obstructive Pulmonary Disease), which is not on this map. Cited by 34 papers, 6 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Influence of Frailty on Cardiovascular Events and Mortality in Patients With Chronic Obstructive Pulmonary Disease (COPD): A Multicentre Observational Study.
Who cites it
34 citing papers in PubMed, 6 syntheses or guidelines pooled it, 58 citations in OpenAlex.
- The impact of frailty on clinical outcomes among individuals with COPD: a systematic review and meta-analysis.BMC pulmonary medicine · 2025Pooled it
- Frailty in COPD: Clinical Impact, Diagnosis, Biomarkers, and Management Strategies.International journal of chronic obstructive pulmonary disease · 2025Pooled it
- Frailty and its influence on mortality and morbidity in COPD: A Systematic Review and Meta-Analysis.Internal and emergency medicine · 2023Pooled it
- Prevalence and risk factors of frailty in patients with chronic obstructive pulmonary disease: systematic review and meta-analysis.European geriatric medicine · 2023Pooled it
- Prevalence and clinical impact of frailty in COPD: a systematic review and meta-analysis.BMC pulmonary medicine · 2023Pooled it
- Systematic review and meta-analysis of prevalence, trajectories, and clinical outcomes for frailty in COPD.NPJ primary care respiratory medicine · 2023Pooled it
- Frailty and COPD: a bidirectional relationship in the context of systemic and accelerated ageing.European respiratory review : an official journal of the European Respiratory Society · 2026Review
- Frailty Is a Predictor of Disability, Hospitalization and Mortality in Older Adults with COPD: A Longitudinal Study.Journal of clinical medicine · 2026Article
- Association between frailty and the risks of chronic pulmonary diseases and lung cancer.BMC pulmonary medicine · 2026Article
- Genetic and Molecular Interconnections Between Chronic Obstructive Pulmonary Disease and Osteoporosis: Insights from Single-Cell and Mendelian Randomization Analyses.International journal of chronic obstructive pulmonary disease · 2026Article
- Explainable machine learning model for 1-year readmission risk prediction in AECOPD patients: integrating relief feature selection with sample augmentation.BMC infectious diseases · 2025Article
- Prevalence, Persistence, and Agreement of Physical Frailty Tools in Patients with Severe COPD Declining Pulmonary Rehabilitation: An Exploratory 1-Year Prospective Cohort Study.Journal of clinical medicine · 2025Article
- Article
- The predictive role of identifying frailty in assessing the need for palliative care in the elderly: the application of machine learning algorithm.Journal of health, population, and nutrition · 2025Article
- Predicting poor self-management behaviors in adults with newly diagnosed COPD: based on the information-motivation-behavioral skills model.BMC public health · 2025Article
- Association between chronic respiratory diseases and frailty in Chinese elderly: a population-based longitudinal study.BMJ open respiratory research · 2025Article
- Association of Patient-Reported Outcome Patterns and Major Clinical Factors with Frailty in Stable COPD.International journal of chronic obstructive pulmonary disease · 2025Article
- The Associations between Albumin, Globulin, Albumin-to-globulin Ratio, and Frailty in Middle-aged and Older Adults: Evidence from NHANES 2013-2014.Current pharmaceutical design · 2025Article
- Relationship Between COPD Progression and Frailty Progression: A Five-year Observation in Real Clinical Practice.International journal of chronic obstructive pulmonary disease · 2025Observational
- Impact of Frailty on Symptom Burden in Chronic Obstructive Pulmonary Disease.Journal of clinical medicine · 2024Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
rationaleFor the high prevalence of frail in patients with chronic obstructive pulmonary disease (COPD), further study should explore an in-depth understanding of the relationship between frailty and prognosis of COPD.
objectiveTo determine the correlation between frailty and risk of acute exacerbation, hospitalizations, and mortality in older patients with stable COPD. PARTICIPANTS AND
methodsConsecutive older adults (≥65) diagnosed with stable COPD from January 2018 to July 2019, with an average follow-up of 546 days (N = 309). Frailty was defined by the Fried frailty phenotype. Poisson regression was performed to assess the influence of frailty on the incidence of acute exacerbations of COPD (AECOPD) and all-cause hospitalizations in a year. Cox regression was performed to evaluate the effect of frailty on all-cause mortality in patients with stable COPD.
resultsThe prevalence of frailty was 49.8%. The most common phenotypic characteristics were weakness (99.4%) followed by slowness (92.9%). After adjustment, frailty increased the incidence of AECOPD (IRR = 1.75, 95% CI: 1.09-2.82) and all-cause hospitalizations (IRR = 1.39, 95% CI 1.04-1.87) within a year. Slowness was associated with AECOPD (IRR = 1.77, 95% CI: 1.03-3.03), and weakness was associated with increased all-cause hospitalizations (IRR = 1.53, 95% CI: 1.04-2.25). The all-cause mortality risk was more than twofold higher in frail patients (HR = 2.54, 95% CI: 1.01-6.36) than non-frail patients. Low physical activity (HR = 2.66, 95% CI: 1.17-6.05) and weight loss (HR = 2.15, 95% CI: 1.02-4.51) were significantly associated with increased all-cause mortality in patients with COPD.
conclusionFrailty increased the incidence of acute exacerbation and hospitalization, as well as increased mortality in older patients with stable COPD. This knowledge will help physicians identify high-risk groups with COPD and frailty who may benefit from targeted interventions to prevent disease progression.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.