Evidence map›Paper›PMID 33879864›Full record

ReviewMolecular psychiatry2022

Evolution of genetic networks for human creativity.

I Zwir, C Del-Val, M Hintsanen, K M Cloninger, R Romero-Zaliz, A Mesa, J Arnedo, R Salas, G F Poblete, E Raitoharju and 6 more

Open access · hybridAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Molecular psychiatry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed
16.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 106 citations in OpenAlex.

  1. Article
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  7. Perceptions of Monica Geller inBehavioral sciences (Basel, Switzerland) · 2025
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  8. Review
  9. Article
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  12. A neural network for religious fundamentalism derived from patients with brain lesions.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  13. Review
  14. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 9 institutions in 4 countries.

I Zwir *Department of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA.ORCID http://orcid.org/0000-0002-1443-0234
C Del-Val *Department of Computer Science and Artificial Intelligence, University of Granada, Andalusian Research Institute in Data Science and Computational Intelligence, Granada, Spain.ORCID http://orcid.org/0000-0002-2212-2039
M HintsanenUnit of Psychology, Faculty of Education, University of Oulu, Oulu, Finland.ORCID http://orcid.org/0000-0003-2673-0901
K M CloningerAnthropedia Foundation, St. Louis, MO, USA.ORCID http://orcid.org/0000-0003-2049-2658
R Romero-ZalizDepartment of Computer Science and Artificial Intelligence, University of Granada, Andalusian Research Institute in Data Science and Computational Intelligence, Granada, Spain.
A MesaDepartment of Computer Science and Artificial Intelligence, University of Granada, Andalusian Research Institute in Data Science and Computational Intelligence, Granada, Spain.
J ArnedoDepartment of Computer Science and Artificial Intelligence, University of Granada, Andalusian Research Institute in Data Science and Computational Intelligence, Granada, Spain.
R SalasThe Menninger Clinic, Baylor College of Medicine, and DeBakey VA Medical Center, Houston, TX, USA.ORCID http://orcid.org/0000-0002-1105-566X
G F PobleteThe Menninger Clinic, Baylor College of Medicine, and DeBakey VA Medical Center, Houston, TX, USA.ORCID http://orcid.org/0000-0002-3806-235X
E RaitoharjuDepartment of Clinical Chemistry, Fimlab Laboratories, and Finnish Cardiovascular Research Center - Tampere, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.
O RaitakariCenter for Population Health Research, University of Turku and Turku University Hospital; Research Center of Applied and Preventive Cardiovascular Medicine, University of Turku; Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital, Turku, Finland.
L Keltikangas-JärvinenDepartment of Psychology and Logopedics, University of Helsinki, Helsinki, Finland.
G A de ErausquinDepartment of Psychiatry, University of Texas San Antonio, Long School of Medicine, The Glenn Briggs Institute of Alzheimer's and Neurodegenerative Disorders, San Antonio, TX, USA.ORCID http://orcid.org/0000-0001-6423-4461
I TattersallAmerican Museum of Natural History, New York, NY, USA.
T LehtimäkiDepartment of Clinical Chemistry, Fimlab Laboratories, and Finnish Cardiovascular Research Center - Tampere, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.ORCID http://orcid.org/0000-0002-2555-4427
C R CloningerDepartment of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA. crcloninger44@gmail.com.ORCID http://orcid.org/0000-0003-3096-4807
Universidad de Granada · ESBaylor College of Medicine · USTampere University · FIAmerican Museum of Natural History · USInstitute for Neurodegenerative Disorders · USUniversity of Helsinki · FIUniversity of Oulu · FIUniversity of Turku · FIWashington University in St. Louis · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The genetic basis for the emergence of creativity in modern humans remains a mystery despite sequencing the genomes of chimpanzees and Neanderthals, our closest hominid relatives. Data-driven methods allowed us to uncover networks of genes distinguishing the three major systems of modern human personality and adaptability: emotional reactivity, self-control, and self-awareness. Now we have identified which of these genes are present in chimpanzees and Neanderthals. We replicated our findings in separate analyses of three high-coverage genomes of Neanderthals. We found that Neanderthals had nearly the same genes for emotional reactivity as chimpanzees, and they were intermediate between modern humans and chimpanzees in their numbers of genes for both self-control and self-awareness. 95% of the 267 genes we found only in modern humans were not protein-coding, including many long-non-coding RNAs in the self-awareness network. These genes may have arisen by positive selection for the characteristics of human well-being and behavioral modernity, including creativity, prosocial behavior, and healthy longevity. The genes that cluster in association with those found only in modern humans are over-expressed in brain regions involved in human self-awareness and creativity, including late-myelinating and phylogenetically recent regions of neocortex for autobiographical memory in frontal, parietal, and temporal regions, as well as related components of cortico-thalamo-ponto-cerebellar-cortical and cortico-striato-cortical loops. We conclude that modern humans have more than 200 unique non-protein-coding genes regulating co-expression of many more protein-coding genes in coordinated networks that underlie their capacities for self-awareness, creativity, prosocial behavior, and healthy longevity, which are not found in chimpanzees or Neanderthals.

Indexed as

CreativityGene Regulatory NetworksRNA, Long NoncodingAnimalsBrainEvolution, MolecularHumansNeanderthalsPan troglodytesRNA, Long Noncoding

Identifiers

PMID33879864
PMCPMC8960414
OpenAlexW3154720110

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.