Evidence map›Paper›PMID 33879860›Full record

ArticleExperimental & molecular medicine2021

Multiplexed targeting of miRNA-210 in stem cell-derived extracellular vesicles promotes selective regeneration in ischemic hearts.

Byeong-Wook Song, Chang Youn Lee, Ran Kim, Won Jung Kim, Hee Won Lee, Min Young Lee, Jongmin Kim, Jee-Yeong Jeong, Woochul Chang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Experimental & molecular medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
1.6field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 29 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 6 institutions in 1 country.

Byeong-Wook SongInstitute for Bio-Medical Convergence, Catholic Kwandong University International St. Mary's Hospital, Incheon, Republic of Korea.ORCID http://orcid.org/0000-0002-9962-0941
Chang Youn LeeDepartment of Integrated Omics for Biomedical Sciences, Graduate School, Yonsei University, Seoul, Republic of Korea.
Ran KimDepartment of Biology Education, College of Education, Pusan National University, Busan, Republic of Korea.
Won Jung KimDepartment of Biology Education, College of Education, Pusan National University, Busan, Republic of Korea.
Hee Won LeeDepartment of Biology Education, College of Education, Pusan National University, Busan, Republic of Korea.
Min Young LeeDepartment of Molecular Physiology, College of Pharmacy, Kyungpook National University, Daegu, Republic of Korea.
Jongmin KimDepartment of Life Systems, Sookmyung Women's University, Seoul, Republic of Korea.
Jee-Yeong JeongDepartment of Biochemistry, Kosin University College of Medicine, Busan, Republic of Korea.ORCID http://orcid.org/0000-0001-9482-4526
Woochul ChangDepartment of Biology Education, College of Education, Pusan National University, Busan, Republic of Korea. wchang1975@pusan.ac.kr.
Pusan National University · KRCatholic Kwandong University International St. Mary's Hospital · KRKosin University · KRKyungpook National University · KRSookmyung Women's University · KRYonsei University · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Extracellular vesicles (EVs) are cell derivatives containing diverse cellular molecules, have various physiological properties and are also present in stem cells used for regenerative therapy. We selected a "multiplexed target" that demonstrates multiple effects on various cardiovascular cells, while functioning as a cargo of EVs. We screened various microRNAs (miRs) and identified miR-210 as a candidate target for survival and angiogenic function. We confirmed the cellular and biological functions of EV-210 (EVs derived from ASC

Indexed as

AnimalsCells, CulturedExtracellular VesiclesHumansHuman Umbilical Vein Endothelial CellsHypoxiaMaleMesenchymal Stem CellsMicroRNAsModels, BiologicalMyocardial IschemiaMyocytes, CardiacRatsRegenerationStem CellsTransfectionMicroRNAsMIRN210 microRNA, human

Identifiers

PMID33879860
PMCPMC8102609
OpenAlexW3154070135

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.