Trial reportPediatric research2021
Cerebral oxygen saturation and autoregulation during hypotension in extremely preterm infants.
Trial report in Pediatric research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 3 syntheses or guidelines pooled it, 30 citations in OpenAlex.
- Cerebral near-infrared spectroscopy monitoring for prevention of death or neurodevelopmental disability in very preterm infants.The Cochrane database of systematic reviews · 2026Pooled it
- Cerebrovascular autoregulation and preterm brain injury: a systematic review and meta-analysis.Pediatric research · 2025Pooled it
- European Consensus Guidelines on the Management of Respiratory Distress Syndrome: 2022 Update.Neonatology · 2023Guideline
- Cerebral Oximetry in Extremely Preterm Infants: 2-Year Follow-Up of the SafeBoosC-III Randomized Clinical Trial.JAMA pediatrics · 2026Trial
- Outcomes of extremely preterm infants who participated in a randomised trial of dopamine for treatment of hypotension (the HIP trial) at 2 years corrected age.Archives of disease in childhood. Fetal and neonatal edition · 2025Trial
- Cerebral autoregulation in pediatric and neonatal intensive care: A scoping review.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2024Article
- Near-infrared spectroscopy monitoring of neonatal cerebrovascular reactivity: where are we now?Pediatric research · 2024Review
- Cerebrovascular Autoregulation in Preterm Infants Using Heart Rate or Blood Pressure: A Pilot Study.Children (Basel, Switzerland) · 2024Article
- An Update on Pharmacologic Management of Neonatal Hypotension: When, Why, and Which Medication.Children (Basel, Switzerland) · 2024Review
- Monitoring and evaluation of hypotension in the extremely preterm.Frontiers in cardiovascular medicine · 2024Review
- [Risk factors and prognosis of hypotension within 72 hours after birth in extremely preterm infants].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2023Article
- A study protocol for investigating the sonographic characteristics of neonates with critical illness: an observational cohort study.BMJ paediatrics open · 2023Article
- Pathogenesis and Prevention of Intraventricular Hemorrhage in Preterm Infants.Journal of Korean Neurosurgical Society · 2023Article
- Evaluation of the Hypotensive Preterm Infant: Evidence-Based Practice at the Bedside?Children (Basel, Switzerland) · 2023Review
- Clinical determinants of cerebrovascular reactivity in very preterm infants during the transitional period.Pediatric research · 2022Observational
- Correlation between arterial blood pressures and regional cerebral oxygen saturation in preterm neonates during postnatal transition-an observational study.Frontiers in pediatrics · 2022Article
- Cerebral Oxygenation and Metabolism After Hypoxia-Ischemia.Frontiers in pediatrics · 2022Review
- How to safeguard the brain of extremely preterm infants?Pediatric research · 2021Article
- Cerebral Oximetry in Preterm Infants-To Use or Not to Use, That Is the Question.Frontiers in pediatrics · 2021Article
Corrections and comments
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Authors and funding
19 authors at 15 institutions in 6 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe impact of the permissive hypotension approach in clinically well infants on regional cerebral oxygen saturation (rScO
methodsProspective cohort study of blinded rScO
resultsIn 89 potentially eligible HIP trial patients with rScO
conclusionsDopamine had no effect on rScO IMPACT: Treatment of hypotension with dopamine in extremely preterm infants increases mean arterial blood pressure, but does not improve cerebral oxygenation. Hypotensive extremely preterm infants have increased duration of cerebral hypoxia and reduced cerebral autoregulatory capacity compared to non-hypotensive infants. Duration of cerebral hypoxia and hypotension are associated with early intraventricular hemorrhage or death in extremely preterm infants. Since systematic treatment of hypotension may not be associated with better outcomes, the diagnosis of cerebral hypoxia in hypotensive extremely preterm infants might guide treatment.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.