Evidence map›Paper›PMID 33879807›Full record

ArticleScientific reports2021

Growth hormone deficiency testing and treatment following mild traumatic brain injury.

Leah J Mercier, Natalia Kruger, Quynk B Le, Tak S Fung, Gregory A Kline, Chantel T Debert

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05660356 (Growth Hormone Deficiency in Patients With Persistent Symptoms Following Concussion), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.6field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05660356 early_phase1unknown statusnot on this mapstarted 2023, after this paper: background citation

Growth Hormone Deficiency in Patients With Persistent Symptoms Following Concussion

TypeinterventionalSponsorUniversity of CalgaryRan2023 to 2025Enrolled20ConditionsGrowth Hormone Treatment, Growth Hormone Deficiency, Concussion, Mild, Concussion Post SyndromeArmsGrowth Hormone, Placebo
3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 11 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Leah J MercierDivision of Physical Medicine and Rehabilitation, Department of Clinical Neurosciences, University of Calgary, Calgary, AB, Canada. leah.mercier@ucalgary.ca.
Natalia KrugerDivision of Physical Medicine and Rehabilitation, Department of Clinical Neurosciences, University of Calgary, Calgary, AB, Canada.
Quynk B LeEndocrinology and Metabolism Program, Alberta Health Services, Calgary, AB, Canada.
Tak S FungFaculty of Nursing, University of Calgary, Calgary, AB, Canada.
Gregory A KlineDivision of Endocrinology, Department of Medicine, University of Calgary, Calgary, AB, Canada.
Chantel T DebertDivision of Physical Medicine and Rehabilitation, Department of Clinical Neurosciences, University of Calgary, Calgary, AB, Canada.
University of Calgary · CAAlberta Health Services · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pituitary dysfunction, specifically growth hormone (GH) deficiency, can occur following traumatic brain injury. Our objective was to characterize the prevalence of GH deficiency (GHD) testing and response to recombinant human GH (rhGH) treatment in adults with persistent symptoms following mild traumatic brain injury (mTBI) referred for assessment of pituitary dysfunction. A retrospective chart review was conducted of patients seen at an outpatient brain injury clinic with a diagnosis of mTBI and persistent post-concussive symptoms who were referred to endocrinology. Clinical assessments of symptoms were collected. Investigations and results of GHD were collected, including initiation of rhGH treatment and treatment response. Of the 253 patients seen in both brain injury and endocrinology clinics, 97 with mTBI were referred for investigation of pituitary dysfunction and 73 (75%) had dynamic testing for assessment of GHD. Of the 26 individuals diagnosed with GHD, 23 (88%) started rhGH. GH therapy was inconsistently offered based on interpretation of GH dynamic testing results. Of those who started rhGH, 18 (78%) had a useful treatment response. This study suggests that clinical management of these patients is varied, highlighting a need for clear guidelines for the diagnosis and management of GHD following mTBI.

Indexed as

AdultBrain ConcussionFemaleGrowth DisordersHuman Growth HormoneHumansInsulin-Like Growth Factor IMalePost-Concussion SyndromePrevalenceRetrospective StudiesTreatment OutcomeHuman Growth HormoneInsulin-Like Growth Factor I

Identifiers

PMID33879807
PMCPMC8058058
OpenAlexW3154117305

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.