Evidence map›Paper›PMID 33879768›Full record

ArticleCell death & disease2021

Mitochondrial quality control protects photoreceptors against oxidative stress in the H

Biting Zhou, Lijun Fang, Yanli Dong, Juhua Yang, Xiaole Chen, Nanwen Zhang, Yihua Zhu, Tianwen Huang

Open access · goldAbstract read
In one paragraph

Article in Cell death & disease, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
5.0field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 46 citations in OpenAlex.

  1. Protective effects ofHistology and histopathology · 2026
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  15. The Genetic Selection ofAnimals : an open access journal from MDPI · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Biting Zhou *Department of Ophthalmology, The First Affiliated Hospital of Fujian Medical University, Fuzhou, Fujian, China.
Lijun Fang *Department of Ophthalmology, Fujian Medical University Union Hospital, Fuzhou, Fujian, China.ORCID 0000-0001-8590-3994
Yanli DongQiqihaer Food and Drug Control Center, Qiqihaer, Heilongjiang, China.
Juhua YangDepartment of Bioengineering and Biopharmaceutics, School of Pharmacy, Fujian Medical University, Fuzhou, Fujian, China.
Xiaole ChenDepartment of Bioengineering and Biopharmaceutics, School of Pharmacy, Fujian Medical University, Fuzhou, Fujian, China.
Nanwen ZhangDepartment of Pharmacology, School of Pharmacy, Fujian Medical University, Fuzhou, Fujian, China.
Yihua ZhuDepartment of Ophthalmology, The First Affiliated Hospital of Fujian Medical University, Fuzhou, Fujian, China. zhuyihua889@163.com.ORCID 0000-0003-2491-669X
Tianwen HuangDepartment of Neurology, Fujian Medical University Union Hospital, Fuzhou, Fujian, China. huangtianwen2002@163.com.ORCID 0000-0001-5039-6259
Fujian Medical University · CNQiqihar University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Retinal degeneration diseases (RDDs) are common and devastating eye diseases characterized by the degeneration of photoreceptors, which are highly associated with oxidative stress. Previous studies reported that mitochondrial dysfunction is associated with various neurodegenerative diseases. However, the role of mitochondrial proteostasis mainly regulated by mitophagy and mitochondrial unfolded protein response (mtUPR) in RDDs is unclear. We hypothesized that the mitochondrial proteostasis is neuroprotective against oxidative injury in RDDs. In this study, the data from our hydrogen peroxide (H

Indexed as

AnimalsDisease Models, AnimalHumansHydrogen PeroxideMiceMitochondriaOxidative StressPhotoreceptor Cells, VertebrateQuality ControlRetinal DegenerationHydrogen Peroxide

Identifiers

PMID33879768
PMCPMC8058096
OpenAlexW3156557484

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.