ArticleTranslational psychiatry2021
Transdiagnostic dimensions of psychopathology explain individuals' unique deviations from normative neurodevelopment in brain structure.
Article in Translational psychiatry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 62 papers, 2 of them syntheses that pooled it.
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Who cites it
62 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Neural circuit disruptions of eye gaze processing in autism spectrum disorder and schizophrenia: An activation likelihood estimation meta-analysis.Schizophrenia research · 2024Pooled it
- Normative Modeling of Brain Morphometry in Clinical High Risk for Psychosis.JAMA psychiatry · 2024Pooled it
- Attention and learning strategies reveal distinct dimensions of psychiatric diseases.Research square · 2026Article
- Widespread use of invalid statistical tests in biomedical machine learning.bioRxiv : the preprint server for biology · 2026Article
- Shared neurogenetic architecture links adolescent neurodevelopmental deviations to adult psychopathological procrastination.Molecular psychiatry · 2026Article
- Neurobiological Signatures of Dyadic Transmission of Fear Extinction in Adolescent Trauma Exposure and Posttraumatic Stress.Biological psychiatry global open science · 2026Article
- Neural and physiological correlates of parent-child observational threat extinction.Scientific reports · 2025Article
- Mapping Neurochemical Signatures onto Brain Structure for Neurotransmitter-Informed Discrimination of Schizophrenia Patients from Healthy Controls.medRxiv : the preprint server for health sciences · 2025Article
- Endophenotype Research in Epilepsy Across Time.Brain sciences · 2025Article
- Article
- The broad structure of psychopathology in the All of Us Research Program.Psychological medicine · 2025Article
- Modeling psychopathology in high-dimensional vector space using the high-dimensional symptom space (HDSS) model can operationalize precision psychiatry in US adolescents.Scientific reports · 2025Article
- Statistical variability in comparing accuracy of neuroimaging based classification models via cross validation.Scientific reports · 2025Article
- Prospective Relations between Cortical Thickness and Change in Internalizing Symptoms are Moderated by Chronic Stress Exposure in Adolescents with Depression and Anxiety.Clinical psychological science : a journal of the Association for Psychological Science · 2025Article
- Longitudinal Development of Neurocognitive Functioning and Gray Matter Volume in Youths With Recurrent Psychosis Spectrum Symptoms.Schizophrenia bulletin · 2025Article
- Beyond out-of-sample: robust and generalizable multivariate neuroanatomical patterns of psychiatric problems in youth.Molecular psychiatry · 2025Article
- A longitudinal investigation of the relationship between dimensional psychopathology, gray matter structure, and dementia status in older adulthood.Psychological medicine · 2025Article
- Mapping the neurodevelopmental predictors of psychopathology.Molecular psychiatry · 2025Article
- Spectral normative modeling of brain structure.medRxiv : the preprint server for health sciences · 2025Article
- Interpretable and integrative deep learning for discovering brain-behaviour associations.Scientific reports · 2025Article
2 more citing papers are in PubMed but not listed here.
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11 authors.
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Abstract
Psychopathology is rooted in neurodevelopment. However, clinical and biological heterogeneity, together with a focus on case-control approaches, have made it difficult to link dimensions of psychopathology to abnormalities of neurodevelopment. Here, using the Philadelphia Neurodevelopmental Cohort, we built normative models of cortical volume and tested whether deviations from these models better predicted psychiatric symptoms compared to raw cortical volume. Specifically, drawing on the p-factor hypothesis, we distilled 117 clinical symptom measures into six orthogonal psychopathology dimensions: overall psychopathology, anxious-misery, externalizing disorders, fear, positive psychosis symptoms, and negative psychosis symptoms. We found that multivariate patterns of deviations yielded improved out-of-sample prediction of psychopathology dimensions compared to multivariate patterns of raw cortical volume. We also found that correlations between overall psychopathology and deviations in ventromedial prefrontal, inferior temporal, and dorsal anterior cingulate cortices were stronger than those observed for specific dimensions of psychopathology (e.g., anxious-misery). Notably, these same regions are consistently implicated in a range of putatively distinct disorders. Finally, we performed conventional case-control comparisons of deviations in a group of individuals with depression and a group with attention-deficit hyperactivity disorder (ADHD). We observed spatially overlapping effects between these groups that diminished when controlling for overall psychopathology. Together, our results suggest that modeling cortical brain features as deviations from normative neurodevelopment improves prediction of psychiatric symptoms in out-of-sample testing, and that p-factor models of psychopathology may assist in separating biomarkers that are disorder-general from those that are disorder-specific.
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