Evidence map›Paper›PMID 33879608›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2021

Enhanced Ca

Eric Seidel, Julia Schewe, Junhui Zhang, Hoang An Dinh, Sofia K Forslund, Lajos Markó, Nicole Hellmig, Jörg Peters, Dominik N Muller, Richard P Lifton and 3 more

Open access · hybridAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
3.5field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 36 citations in OpenAlex.

  1. Identification of novel functional sites in the CaProceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  2. Review
  3. Article
  4. Article
  5. Review
  6. The genetics of hypertension.Nature reviews. Nephrology · 2026
    Review
  7. Article
  8. Article
  9. Adrenal causes of endocrine hypertension in childhood or adolescence.Journal of endocrinological investigation · 2025
    Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Intracellular Calcium Dynamics in Primary Human Adrenocortical Cells Deciphered with a Novel Pipeline.High blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension · 2024
    Article
  15. Article
  16. Article
  17. Article
  18. Genetics of Primary Aldosteronism.Hypertension (Dallas, Tex. : 1979) · 2022
    Review
  19. Enhanced CaProceedings of the National Academy of Sciences of the United States of America · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 2 countries.

Eric SeidelDepartment of Nephrology, Charité-Universitätsmedizin Berlin, 10115 Berlin, Germany.ORCID 0000-0003-3334-3950
Julia ScheweDepartment of Nephrology, Charité-Universitätsmedizin Berlin, 10115 Berlin, Germany.ORCID 0000-0002-7691-4533
Junhui ZhangDepartment of Genetics, Yale University School of Medicine, New Haven, CT 06519.ORCID 0000-0003-0049-8032
Hoang An DinhDepartment of Nephrology, Charité-Universitätsmedizin Berlin, 10115 Berlin, Germany.ORCID 0000-0002-7367-997X
Sofia K ForslundBerlin Institute of Health at Charité-Universitätsmedizin Berlin, 10117 Berlin, Germany.ORCID 0000-0003-4285-6993
Lajos MarkóBerlin Institute of Health at Charité-Universitätsmedizin Berlin, 10117 Berlin, Germany.ORCID 0000-0003-0840-5697
Nicole HellmigDepartment of Nephrology, Charité-Universitätsmedizin Berlin, 10115 Berlin, Germany.
Jörg PetersDepartment of Physiology, Universitätsmedizin Greifswald, 17475 Greifswald, Germany.
Dominik N MullerBerlin Institute of Health at Charité-Universitätsmedizin Berlin, 10117 Berlin, Germany.
Richard P LiftonDepartment of Genetics, Yale University School of Medicine, New Haven, CT 06519; rickl@rockefeller.edu ute.scholl@charite.de.
Timothy NottoliSection of Comparative Medicine, Yale Genome Editing Center, Yale University School of Medicine, New Haven, CT 06519.ORCID 0000-0002-2218-5590
Gabriel StöltingDepartment of Nephrology, Charité-Universitätsmedizin Berlin, 10115 Berlin, Germany.ORCID 0000-0002-2339-0545
Ute I SchollDepartment of Nephrology, Charité-Universitätsmedizin Berlin, 10115 Berlin, Germany; rickl@rockefeller.edu ute.scholl@charite.de.ORCID 0000-0002-0309-8045
Berlin Institute of Health at Charité - Universitätsmedizin Berlin · DEHelmholtz Association of German Research Centres · DEYale University · USUniversitätsmedizin Greifswald · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Gain-of-function mutations in the

Indexed as

AldosteroneAnimalsBlood PressureCalcium ChannelsCalcium Channels, T-TypeCalcium SignalingCytochrome P-450 CYP11B2Disease Models, AnimalGain of Function MutationHyperaldosteronismHypertensionMaleMiceMice, Inbred C57BLMutationAldosteroneCacna1h protein, mouseCalcium ChannelsCalcium Channels, T-TypeCytochrome P-450 CYP11B2adrenal glandcalcium imagingCaV3.2

Identifiers

PMID33879608
PMCPMC8092574
OpenAlexW3154488739

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.