ArticleRMD open2021
Application of the OMERACT Grey-scale Ultrasound Scoring System for salivary glands in a single-centre cohort of patients with suspected Sjögren's syndrome.
Article in RMD open, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
31 citing papers in PubMed, 44 citations in OpenAlex.
- Ophthalmic Treatments and Evolving Management of Sjögren's Disease: An Overview.Journal of clinical medicine · 2026Review
- Ultra-high frequency ultrasound of labial salivary glands in Sjögren's disease: diagnostic accuracy and patient stratification.RMD open · 2026Article
- From Sjögren syndrome to Sjögren disease: rethinking classification and diagnostic complexity.The Korean journal of internal medicine · 2026Review
- Salivary gland ultrasonographic abnormalities in systemic lupus erythematosus versus rheumatoid arthritis: a comparative cross-sectional study using OMERACT scoring.Journal of ultrasound · 2026Article
- Ultrasonographic Evaluation of Salivary Gland Stiffness in Primary Sjögren's Disease and Idiopathic Xerostomia.Oral diseases · 2026Article
- Imaging correlates of disease activity and patient-reported symptoms in primary Sjögren's disease: an ultrasonographic and scintigraphic study.Rheumatology international · 2026Article
- Diagnostic performance of conventional ultrasound and shear wave elastography of the parotid glands in primary Sjögren's syndrome.BMC medical imaging · 2026Article
- Article
- Diagnostic utility of salivary gland ultrasonography in suspected primary Sjögren's disease: a comparison of OMERACT-based ordinal and summative scoring.Arthritis research & therapy · 2026Article
- Usefulness of salivary gland ultrasonography in Sjögren's syndrome: The Tunisian Experience.Clinical rheumatology · 2026Article
- Increased lymphoma risk in patients with systemic manifestations of Sjögren's disease: a population-based study.Frontiers in medicine · 2026Article
- The agreement of the OMERACT grey-scale ultrasound scoring system for salivary glands and minor salivary gland biopsy results in a single-center cohort of patients with suspected Sjögren's disease.Skeletal radiology · 2025Article
- Diagnostic value of high-frequency ultrasound assessment of the lacrimal glands for primary Sjögren's disease.RMD open · 2025Article
- Case Series of Changes in Greyscale and Power Doppler Signals on Salivary Gland Ultrasonography after Treatment in Patients with Sjögren's Syndrome.Internal medicine (Tokyo, Japan) · 2024Article
- The power of us: breaking barriers and bridging the gap of ultrasound in rheumatology to empower a new generation.Clinical rheumatology · 2024Article
- [Update on Sjögren's syndrome : Diagnostics, treatment, and challenges].Zeitschrift fur Rheumatologie · 2024Article
- Anti-centromere antibody positivity is an independent variable associated with salivary gland ultrasonography score in Sjögren's syndrome.Scientific reports · 2024Article
- The Role of Major Salivary Gland Ultrasound in the Diagnostic Workup of Sicca Syndrome: A Large Single-Centre Study.Tomography (Ann Arbor, Mich.) · 2024Article
- The impact of an ultrasound atlas for scoring salivary glands in primary Sjögren's syndrome: a pilot study.Clinical rheumatology · 2023Article
- [Salivary gland ultrasound or biopsy? : Comparison of methods based on case examples].Zeitschrift fur Rheumatologie · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo describe salivary gland involvement in patients suspected of Sjögren's syndrome (SS) using the OMERACT Ultrasound Scoring System for SS. Next, using different ultrasound cut-offs, to assess the performance of the scoring system for diagnosis and fulfilment of 2016 ACR/EULAR SS classification criteria.
methodsAll patients referred to our department with a suspicion of SS in a 12-month period were included. All underwent grey-scale ultrasound of the parotid and submandibular glands prior to clinical examination, Schirmer's test, unstimulated salivary flow, blood samples including autoantibody analysis. Labial biopsy was performed according to clinicians' judgement. Images of the four glands were scored 0-3 according to the scoring system and a consensus score was obtained using a developed ultrasound atlas.
resultsOf the 134 patients included in the analysis, 43 were diagnosed with primary SS (pSS) and all fulfilled the 2016 American College of Rheumatology (ACR)/EULAR classification criteria. More patients with pSS compared with non-pSS had score ≥2 in at least one gland (72% vs 13%; p<0.001). In patients with score ≥2 in any gland, significantly more had positive autoantibodies, sialometry, Schirmer's test and positive labial biopsy compared with those with scores ≤1. The best ultrasound cut-off value for diagnosing pSS was ≥1 gland with a score ≥2 (sensitivity=0.72, specificity=0.91).
conclusionThe OMERACT Ultrasound Scoring System showed good sensitivity (0.72) and excellent specificity (0.91) for fulfilling 2016 ACR/EULAR criteria using cut-off score >2 in at least one gland. Our data supports the use of ultrasound for diagnosing pSS and supports incorporation of ultrasound in the classification criteria.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.