Evidence map›Paper›PMID 33879580›Full record

ArticleJournal of immunology (Baltimore, Md. : 1950)2021

BATF Regulates T Regulatory Cell Functional Specification and Fitness of Triglyceride Metabolism in Restraining Allergic Responses.

Chengxian Xu, Yongyao Fu, Sheng Liu, Jack Trittipo, Xiaoyu Lu, Rong Qi, Hong Du, Cong Yan, Chi Zhang, Jun Wan and 2 more

Open access · greenAbstract readComment
In one paragraph

Article in Journal of immunology (Baltimore, Md. : 1950), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
1.6field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 29 citations in OpenAlex.

  1. Article
  2. Antigen-specific TScience advances · 2026
    Article
  3. Review
  4. Review
  5. Review
  6. Review
  7. Article
  8. Article
  9. Review
  10. Review
  11. Review
  12. Review
  13. Review
  14. Article
  15. Review
  16. Article
  17. Article
  18. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Chengxian XuHerman B Wells Center for Pediatric Research, Department of Pediatrics, Indiana University School of Medicine, Indianapolis, IN.
Yongyao FuDepartment of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, IN.
Sheng LiuCenter for Computational Biology and Bioinformatics, Indiana University School of Medicine, Indianapolis, IN.
Jack TrittipoHerman B Wells Center for Pediatric Research, Department of Pediatrics, Indiana University School of Medicine, Indianapolis, IN.ORCID 0000-0003-1231-4691
Xiaoyu LuCenter for Computational Biology and Bioinformatics, Indiana University School of Medicine, Indianapolis, IN.ORCID 0000-0002-6211-6215
Rong QiIndiana Biosciences Research Institute, Indianapolis, IN; and.
Hong DuDepartment of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN.ORCID 0000-0001-6652-4702
Cong YanDepartment of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN.
Chi ZhangCenter for Computational Biology and Bioinformatics, Indiana University School of Medicine, Indianapolis, IN.ORCID 0000-0001-9553-0925
Jun WanCenter for Computational Biology and Bioinformatics, Indiana University School of Medicine, Indianapolis, IN.ORCID 0000-0001-9286-6562
Mark H KaplanHerman B Wells Center for Pediatric Research, Department of Pediatrics, Indiana University School of Medicine, Indianapolis, IN.
Kai YangHerman B Wells Center for Pediatric Research, Department of Pediatrics, Indiana University School of Medicine, Indianapolis, IN; ky11@iu.edu.
Indiana University School of MedicineIndiana Biosciences Research Institute · US

Funding

Project-005U54DK106846 · NIDDK · INDIANA UNIVERSITY INDIANAPOLIS · PI Reuben Kapur, Karen Elizabeth Pollok · 2015 to 2026
$9.7M
The role of PU.1 in T helper cell heterogeneityR01AI057459 · NIAID · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI KAPLAN, MARK H · 2005 to 2025
$8.2M
Metabolic Regulation ofPD-L1 in CD11c+ CellsR01CA225108 · NCI · INDIANA UNIVERSITY INDIANAPOLIS · PI DU, HONG, YAN, CONG · 2019 to 2023
$2.7M
Transcriptional and metabolic regulation of Treg cell specification for the control of allergic airway diseaseR01AI153255 · NIAID · INDIANA UNIVERSITY INDIANAPOLIS · PI YANG, KAI · 2021 to 2025
$2.5M
Transcriptional and metabolic regulation of Treg cell specification for the control of allergic airway diseaseR56AI153255 · NIAID · INDIANA UNIVERSITY INDIANAPOLIS · PI YANG, KAI · 2020 to 2020
$317k
NCI NIH HHS R01 CA225108NIAID NIH HHS R01 AI057459NIAID NIH HHS R01 AI153255NIAID NIH HHS R56 AI153255NIDDK NIH HHS U54 DK106846
6 · The paper itself

Abstract

Preserving appropriate function and metabolism in regulatory T (Treg) cells is crucial for controlling immune tolerance and inflammatory responses. Yet how Treg cells coordinate cellular metabolic programs to support their functional specification remains elusive. In this study, we report that BATF couples the T

Indexed as

HypersensitivityT-Lymphocytes, RegulatoryAnimalsBasic-Leucine Zipper Transcription FactorsMiceMice, KnockoutPyroglyphidaeTriglyceridesBasic-Leucine Zipper Transcription FactorsBatf protein, mouseTriglycerides

Identifiers

PMID33879580
PMCPMC8442614
OpenAlexW3156201751

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.