Evidence map›Paper›PMID 33879536›Full record

ArticleDiabetes care2021

Important Drop in Rate of Acute Diabetes Complications in People With Type 1 or Type 2 Diabetes After Initiation of Flash Glucose Monitoring in France: The RELIEF Study.

Ronan Roussel, Jean-Pierre Riveline, Eric Vicaut, Gérard de Pouvourville, Bruno Detournay, Corinne Emery, Fleur Levrat-Guillen, Bruno Guerci

Registry-linked trialOpen access · bronzeAbstract read
In one paragraph

Article in Diabetes care, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07769138 (Implementation of Networked Continuous Glucose Monitoring With Telemetry Within the Intensive Care Unit), which is not on this map. Cited by 75 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
75citing papers in PubMed, 3 pooled it
15.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07769138 not yet recruitingnot on this mapstarted 2026, after this paper: background citation

Implementation of Networked Continuous Glucose Monitoring With Telemetry Within the Intensive Care Unit (ICU-TeleCGM)

TypeobservationalSponsorImperial College Healthcare NHS TrustRan2026 to 2028Enrolled70ConditionsType 1 Diabetes, Type 2 Diabetes Treated With Insulin, Hyperglycemia, Intensive Care (ICU)ArmsDexcom G7, ViewsEMR telemetry
3 · Its place in the literature

Who cites it

75 citing papers in PubMed, 3 syntheses or guidelines pooled it, 161 citations in OpenAlex.

  1. [Diabetes technology (Update 2026)].Wiener klinische Wochenschrift · 2026
    Guideline
  2. Pooled it
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  7. Review
  8. Article
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  12. The Expanding Role of Continuous Glucose Monitoring in the Management and Prevention of Type 2 Diabetes.Diabetes therapy : research, treatment and education of diabetes and related disorders · 2026
    Review
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15 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 6 institutions in 2 countries.

Ronan RousselDepartment of Diabetology, Endocrinology, and Nutrition, Bichat-Claude Bernard Hospital, Paris, France ronan.roussel@gmail.com.ORCID 0000-0003-2292-8363
Jean-Pierre RivelineUnité INSERM U1138 Immunity and Metabolism in Diabetes, ImMeDiab Team, Centre de Recherches des Cordeliers, Paris, France.
Eric VicautClinical Research Unit, Fernand Vidal Hospital, Paris, France.
Gérard de PouvourvilleDepartment of Economics, ESSEC Business School, Cergy-Pontoise, France.
Bruno DetournayCEMKA, Bourg-la-Reine, France.
Corinne EmeryCEMKA, Bourg-la-Reine, France.
Fleur Levrat-GuillenAbbott Laboratories, Maidenhead, Berkshire, U.K.
Bruno GuerciDepartment of Endocrinology, Diabetology, and Nutrition, Brabois Adult Hospital, University of Lorraine, Vandoeuvre-lès-Nancy, France.
Cemka-Eval (France) · FRBerkshire College of Agriculture · GBÉcole Supérieure des Sciences Économiques et Commerciales · FRInserm · FRUniversité Claude Bernard Lyon 1 · FRUniversité de Lorraine · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThe RELIEF study assessed rates of hospitalization for acute diabetes complications in France before and after initiation of the FreeStyle Libre system. RESEARCH DESIGN AND

methodsA total of 74,011 patients with type 1 diabetes or type 2 diabetes who initiated the FreeStyle Libre system were identified from the French national claims database with use of ICD-10 codes, from hospitalizations with diabetes as a contributing diagnosis, or the prescription of insulin. Patients were subclassified based on self-monitoring of blood glucose (SMBG) strip acquisition prior to starting FreeStyle Libre. Hospitalizations for diabetic ketoacidosis (DKA), severe hypoglycemia, diabetes-related coma, and hyperglycemia were recorded for the 12 months before and after initiation.

resultsHospitalizations for acute diabetes complications fell in type 1 diabetes (-49.0%) and in type 2 diabetes (-39.4%) following FreeStyle Libre initiation. DKA fell in type 1 diabetes (-56.2%) and in type 2 diabetes (-52.1%), as did diabetes-related comas in type 1 diabetes (-39.6%) and in type 2 diabetes (-31.9%). Hospitalizations for hypoglycemia and hyperglycemia decreased in type 2 diabetes (-10.8% and -26.5%, respectively). Before initiation, hospitalizations were most marked for people noncompliant with SMBG and for those with highest acquisition of SMBG, which fell by 54.0% and 51.2%, respectively, following FreeStyle Libre initiation. Persistence with FreeStyle Libre at 12 months was at 98.1%.

conclusionsThis large retrospective study on hospitalizations for acute diabetes complications shows that a significantly lower incidence of admissions for DKA and for diabetes-related coma is associated with use of flash glucose monitoring. This study has significant implications for patient-centered diabetes care and potentially for long-term health economic outcomes.

Indexed as

Diabetes Mellitus, Type 2Diabetic KetoacidosisBlood GlucoseBlood Glucose Self-MonitoringHumansRetrospective StudiesBlood Glucose

Identifiers

PMID33879536
PMCPMC8247513
OpenAlexW3152935002

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.