Evidence map›Paper›PMID 33879472›Full record

SynthesisArchives of disease in childhood2021

Ultrasound for the diagnosis of malrotation and volvulus in children and adolescents: a systematic review and meta-analysis.

HaiThuy N Nguyen, Madhulika Kulkarni, Jisha Jose, Amy Sisson, Mary L Brandt, Marla B K Sammer, Mohan Pammi

Open access · greenAbstract readMeta-AnalysisSystematic Review
In one paragraph

Synthesis in Archives of disease in childhood, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
6.9field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 47 citations in OpenAlex.

  1. Article
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  11. [Developmental disorders of the gastrointestinal tract].Radiologie (Heidelberg, Germany) · 2024
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

HaiThuy N NguyenRadiology, Baylor College of Medicine, Houston, Texas, USA.
Madhulika KulkarniPediatrics, Baylor College of Medicine, Houston, Texas, USA.
Jisha JosePediatrics, Baylor College of Medicine, Houston, Texas, USA.
Amy SissonTMC Library, Texas Medical Center, Houston, Texas, USA.
Mary L BrandtSurgery, Tulane University School of Medicine, New Orleans, Louisiana, USA.
Marla B K SammerRadiology, Baylor College of Medicine, Houston, Texas, USA.
Mohan PammiPediatrics, Baylor College of Medicine, Houston, Texas, USA mohanv@bcm.edu.ORCID 0000-0002-5571-6239
Baylor College of Medicine · USTexas Medical Center · USTulane University · US

Funding

Microbiome Induced Epigenetic Changes in Intestinal Inflammation and Necrotizing EnterocolitisR21HD091718 · NICHD · BAYLOR COLLEGE OF MEDICINE · PI PAMMI, MOHAN, SHEN, LANLAN · 2020 to 2021
$422k
Metagenomics of the circulating blood microbiome and systemic inflammation in preterm infantsR03HD098482 · NICHD · BAYLOR COLLEGE OF MEDICINE · PI PAMMI, MOHAN · 2020 to 2021
$160k
NICHD NIH HHS R03 HD098482NICHD NIH HHS R21 HD091718
6 · The paper itself

Abstract

contextDespite the advantages of ultrasound (US), upper gastrointestinal contrast series (UGI) remains the first-line diagnostic modality in the diagnosis of midgut malrotation and volvulus in children.

objectiveEvaluate the diagnostic accuracy of US in the diagnosis of malrotation with or without volvulus in children and adolescents aged 0-21 years, compared with the reference standard (diagnosis by surgery, UGI, CT, MRI, and clinical follow-up individually or as a composite). DATA SOURCES: We searched the electronic databases Ovid-MEDLINE, Embase, Scopus, CINAHL, and the Cochrane library in October 2019 and updated on 18 August 2020. STUDY SELECTION: Studies evaluating the diagnostic performance of US for diagnosis of midgut malrotation with or without volvulus in children (0-21 years). DATA EXTRACTION AND SYNTHESIS: The data were extracted independently by two authors and a bivariate model was used for synthesis.

resultsMeta-analysis of 17 cohort or cross-sectional studies and 2257 participants estimated a summary sensitivity of 94% (95% CI 89% to 97%) and summary specificity of 100% (95% CI 97% to 100%) (moderate certainty evidence) for the use of US for the diagnosis of malrotation with or without midgut volvulus compared with the reference standard. Subgroup analysis and meta-regression revealed better diagnostic accuracy in malrotation not complicated by volvulus, in the neonatal population and enteric fluid administration before US.

conclusionsModerate certainty evidence suggests excellent diagnostic accuracy and coupled with the advantages, a strong case exists for the use of abdominal US as the first-line diagnostic test for suspected midgut malrotation with or without volvulus in children and adolescents.

Indexed as

AdolescentChildChild, PreschoolCross-Sectional StudiesDigestive System AbnormalitiesFemaleHumansInfantInfant, NewbornIntestinal VolvulusMagnetic Resonance ImagingMaleSensitivity and SpecificityUltrasonographygastroenterologyneonatology

Identifiers

PMID33879472
PMCPMC8526644
OpenAlexW3156499638

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.