ArticleParasites & vectors2021
Insecticide resistance status in Anopheles gambiae (s.l.) in coastal Kenya.
Article in Parasites & vectors, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
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Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 56 citations in OpenAlex.
- Effectiveness of dual active ingredient insecticide-treated nets in preventing malaria: A systematic review and meta-analysis.PloS one · 2023Pooled it
- Larvicidal Activity, GC-MS Profiling and Multitarget Molecular Docking of Essential Oils fromMolecules (Basel, Switzerland) · 2026Article
- Modelling the impact of ivermectin-based optimal strategies on malaria control: the role of formulation, coverage, and mosquitocidal efficacy timing.EBioMedicine · 2026Article
- Integrated in silico and in vivo larvicidal evaluation of compounds targeting juvenile hormone for malaria vector control.PloS one · 2026Article
- Malaria prevalence and its determinants across 19 sub-Saharan African countries: a spatial and geographically weighted regression analysis.Malaria journal · 2025Article
- Phenotypic and genotypic insecticide resistance profiles of main malaria vectors in Kwale county, coastal Kenya.Malaria journal · 2025Article
- Omics Approaches in Understanding Insecticide Resistance in Mosquito Vectors.International journal of molecular sciences · 2025Review
- Net ownership, utilization and malaria burden in the context of Piperonyl butoxide-LLINs intervention in western Kenya.PloS one · 2025Article
- Insecticide resistance intensity inCurrent research in parasitology & vector-borne diseases · 2025Article
- A study on the effectiveness of (+)-usnic acid as oral toxic sugar bait against adult male and female Anopheles gambiae.Malaria journal · 2024Article
- Malaria Vector Bionomics: Countrywide Surveillance Study on Implications for Malaria Elimination in India.JMIR public health and surveillance · 2024Article
- Whole transcriptomic analysis reveals overexpression of salivary gland and cuticular proteins genes in insecticide-resistant Anopheles arabiensis from Western Kenya.BMC genomics · 2024Article
- Higher outdoor mosquito density and Plasmodium infection rates in and around malaria index case households in low transmission settings of Ethiopia: Implications for vector control.Parasites & vectors · 2024Article
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- Spatial analyses of Plasmodium knowlesi vectors with reference to control interventions in Malaysia.Parasites & vectors · 2023Article
- A field bioassay for assessing ivermectin bio-efficacy in wild malaria vectors.Malaria journal · 2023Article
- Ace-1 Target Site Status and Metabolic Detoxification Associated with Bendiocarb Resistance in the Field Populations of Main Malaria Vector,Journal of arthropod-borne diseases · 2023Article
- Factors enhancing the transmission of mosquito-borne arboviruses in Africa.Virusdisease · 2022Review
- Vectorial capacity and TEP1 genotypes of Anopheles gambiae sensu lato mosquitoes on the Kenyan coast.Parasites & vectors · 2022Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe rapid and widespread evolution of insecticide resistance has emerged as one of the major challenges facing malaria control programs in sub-Saharan Africa. Understanding the insecticide resistance status of mosquito populations and the underlying mechanisms of insecticide resistance can inform the development of effective and site-specific strategies for resistance prevention and management. The aim of this study was to investigate the insecticide resistance status of Anopheles gambiae (s.l.) mosquitoes from coastal Kenya.
methodsAnopheles gambiae (s.l.) larvae sampled from eight study sites were reared to adulthood in the insectary, and 3- to 5-day-old non-blood-fed females were tested for susceptibility to permethrin, deltamethrin, dichlorodiphenyltrichloroethane (DDT), fenitrothion and bendiocarb using the standard World Health Organization protocol. PCR amplification of rDNA intergenic spacers was used to identify sibling species of the An. gambiae complex. The An. gambiae (s.l.) females were further genotyped for the presence of the L1014S and L1014F knockdown resistance (kdr) mutations by real-time PCR.
resultsAnopheles arabiensis was the dominant species, accounting for 95.2% of the total collection, followed by An. gambiae (s.s.), accounting for 4.8%. Anopheles gambiae (s.l.) mosquitoes were resistant to deltamethrin, permethrin and fenitrothion but not to bendiocarb and DDT. The L1014S kdr point mutation was detected only in An. gambiae (s.s.), at a low allelic frequency of 3.33%, and the 1014F kdr mutation was not detected in either An. gambiae (s.s.) or An. arabiensis.
conclusionThe findings of this study demonstrate phenotypic resistance to pyrethroids and organophosphates and a low level of the L1014S kdr point mutation that may partly be responsible for resistance to pyrethroids. This knowledge may inform the development of insecticide resistance management strategies along the Kenyan Coast.
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