ArticleBMC psychiatry2021
Cortical haemodynamic response during the verbal fluency task in patients with bipolar disorder and borderline personality disorder: a preliminary functional near-infrared spectroscopy study.
Article in BMC psychiatry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
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Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it, 30 citations in OpenAlex.
- fNIRS in Emotional Appraisal and the Dorsolateral Prefrontal Cortex: A Systematic Review.Revista de neurologia · 2025Pooled it
- Brain activation, sleep disturbances, and psychological distress in women undergoing assisted reproductive treatment: a functional near-infrared spectroscopy study.BMC psychology · 2026Article
- Different prefrontal cortex activity patterns in bipolar and unipolar depression during verbal fluency tasks based on functional near infrared spectroscopy study.Scientific reports · 2025Article
- Neural correlates of stress-reactive rumination in depression - The role of childhood trauma and social anxiety.Neurobiology of stress · 2024Article
- The comparison of hot and cold executive functions in patients with bipolar II disorder, borderline personality disorder, and healthy individuals.Annals of medicine and surgery (2012) · 2024Article
- Causal role of immune cells in bipolar disorder: a Mendelian randomization study.Frontiers in psychiatry · 2024Article
- Efficacy of Dialectical Behavior Therapy in the Treatment of Borderline Personality Disorder: A Systematic Review of Randomized Controlled Trials.Iranian journal of psychiatry · 2024Article
- Functional near-infrared spectroscopy in elderly patients with four types of dementia.World journal of psychiatry · 2023Article
- The fNIRS evaluation of frontal and temporal lobe cortical activation in Chinese first-episode medication-naïve and recurrent depression during a verbal fluency task.Frontiers in psychiatry · 2023Article
- Differentiating people with schizophrenia from healthy controls in a developing Country: An evaluation of portable functional near infrared spectroscopy (fNIRS) as an adjunct diagnostic tool.Frontiers in psychiatry · 2023Article
- Intrinsic Organization of Occipital Hubs Predicts Depression: A Resting-State fNIRS Study.Brain sciences · 2022Article
- Therapeutic Interventions to Mitigate Mitochondrial Dysfunction and Oxidative Stress-Induced Damage in Patients with Bipolar Disorder.International journal of molecular sciences · 2022Review
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundFunctional near-infrared spectroscopy (fNIRS) is an emerging neuroimaging modality that provides a direct and quantitative assessment of cortical haemodynamic response during a cognitive task. It may be used to identify neurophysiological differences between psychiatric disorders with overlapping symptoms, such as bipolar disorder (BD) and borderline personality disorder (BPD). Hence, this preliminary study aimed to compare the cerebral haemodynamic function of healthy controls (HC), patients with BD and patients with BPD.
methodsTwenty-seven participants (9 HCs, 9 patients with BD and 9 patients with BPD) matched for age, gender, ethnicity and education were recruited. Relative oxy-haemoglobin and deoxy-haemoglobin changes in the frontotemporal cortex was monitored with a 52-channel fNIRS system during a verbal fluency task (VFT). VFT performance, clinical history and symptom severity were also noted.
resultsCompared to HCs, both patient groups had lower mean oxy-haemoglobin in the frontotemporal cortex during the VFT. Moreover, mean oxy-haemoglobin in the left inferior frontal region is markedly lower in patients with BPD compared to patients with BD. Task performance, clinical history and symptom severity were not associated with mean oxy-haemoglobin levels.
conclusionsPrefrontal cortex activity is disrupted in patients with BD and BPD, but it is more extensive in BPD. These results provide further neurophysiological evidence for the separation of BPD from the bipolar spectrum. fNIRS could be a potential tool for assessing the frontal lobe function of patients who present with symptoms that are common to BD and BPD.
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