Evidence map›Paper›PMID 33879116›Full record

SynthesisBMC pulmonary medicine2021

Medical thoracoscopy treatment for pleural infections: a systematic review and meta-analysis.

Michele Mondoni, Laura Saderi, Federica Trogu, Silvia Terraneo, Paolo Carlucci, Filippo Ghelma, Stefano Centanni, Giovanni Sotgiu

Open access · goldAbstract readMeta-AnalysisSystematic Review
In one paragraph

Synthesis in BMC pulmonary medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
4.8field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 50 citations in OpenAlex.

  1. Article
  2. WABIP/AABIP statement on therapeutic indications of medical thoracoscopy for benign pleural disease.European respiratory review : an official journal of the European Respiratory Society · 2026
    Review
  3. Article
  4. Article
  5. Local management of pleural infection: a narrative review.European journal of medical research · 2026
    Review
  6. What is new in pleural infections?Breathe (Sheffield, England) · 2026
    Review
  7. Observational
  8. Review
  9. Article
  10. Article
  11. Indwelling pleural catheters and medical thoracoscopy.Breathe (Sheffield, England) · 2025
    Review
  12. Review
  13. Article
  14. Review
  15. Reply to RavagliaAmerican journal of respiratory and critical care medicine · 2024
    Article
  16. Article
  17. Review
  18. Review
  19. Diagnosis and management of pleural infection.Breathe (Sheffield, England) · 2023
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Michele MondoniRespiratory Unit, ASST Santi Paolo e Carlo, Department of Health Sciences, Università Degli Studi Di Milano, Via Di Rudinì n. 8, 20142, Milan, Italy. michele.mondoni@asst-santipaolocarlo.it.
Laura SaderiClinical Epidemiology and Medical Statistics Unit, Department of Clinical and Experimental Medicine, University of Sassari, Sassari, Italy.
Federica TroguClinical Epidemiology and Medical Statistics Unit, Department of Clinical and Experimental Medicine, University of Sassari, Sassari, Italy.
Silvia TerraneoRespiratory Unit, ASST Santi Paolo e Carlo, Department of Health Sciences, Università Degli Studi Di Milano, Via Di Rudinì n. 8, 20142, Milan, Italy.
Paolo CarlucciRespiratory Unit, ASST Santi Paolo e Carlo, Department of Health Sciences, Università Degli Studi Di Milano, Via Di Rudinì n. 8, 20142, Milan, Italy.
Filippo GhelmaDisabled Advanced Medical Assistance Unit, Department of Health Sciences, San Paolo Hospital, Università Degli Studi Di Milano, Milan, Italy.
Stefano CentanniRespiratory Unit, ASST Santi Paolo e Carlo, Department of Health Sciences, Università Degli Studi Di Milano, Via Di Rudinì n. 8, 20142, Milan, Italy.
Giovanni SotgiuClinical Epidemiology and Medical Statistics Unit, Department of Clinical and Experimental Medicine, University of Sassari, Sassari, Italy.
University of Sassari · ITOspedale San Paolo · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundComplicated parapneumonic effusions and empyema represent advanced stages of pleural infections and are characterized by a high mortality. Medical thoracoscopy is a safe and minimally invasive endoscopic technique prescribed to treat severe pleural infections. However, only a few studies evaluated its success rate. A systematic review of observational studies was performed to assess the efficacy of medical thoracoscopy in patients with complicated parapneumonic effusions and empyema, as well as its predictive factors.

methodsA search of the scientific evidence was carried out using PubMed, EMBASE, and Cochrane Central Register of Controlled Trials. Articles describing observational studies on medical thoracoscopy in patients with parapneumonic effusions and empyema were selected.

resultsEight studies met the inclusion criteria. The pooled treatment success rate of thoracoscopy was 85% (95% CI 80.0-90.0%; I

conclusionsMedical thoracoscopy is effective and safe when prescribed for complicated parapneumonic effusions and empyema. Bacteriological negativity of pleural effusion specimens and administration of adjuvant intra-pleural fibrinolysis after the procedure are associated with a higher success rate.

Indexed as

ThoracoscopyEmpyema, PleuralExudates and TransudatesHumansPleural EffusionRandomized Controlled Trials as TopicTreatment OutcomeEmpyemaIntra-pleural fibrinolysisMedical thoracoscopyParapneumonic effusionPleural infectionsPleuroscopy

Identifiers

PMID33879116
PMCPMC8056545
OpenAlexW3156781749

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.