Evidence map›Paper›PMID 33879094›Full record

ArticleBMC pulmonary medicine2021

Risk prediction in medically treated chronic thromboembolic pulmonary hypertension.

Ruilin Quan, Yuanhua Yang, Zhenwen Yang, Hongyan Tian, Shengqing Li, Jieyan Shen, Yingqun Ji, Gangcheng Zhang, Caojin Zhang, Guangyi Wang and 13 more

Registry-linked trialAbstract readMulticenter StudyValidation Study
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC pulmonary medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01417338 (National, Prospective, Multicenter,Observational Registry Study on Pulmonary Arterial Hypertension or Chronic Thromboembolic Pulmonary Hypertension in China), which is not on this map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01417338 unknown statusnot on this map

National, Prospective, Multicenter,Observational Registry Study on Pulmonary Arterial Hypertension or Chronic Thromboembolic Pulmonary Hypertension in China

TypeobservationalSponsorChinese Academy of Medical Sciences, Fuwai HospitalRan2009 to 2020Enrolled3,079ConditionsPulmonary Arterial Hypertension, Chronic Thromboembolic Pulmonary Hypertension, Death
3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. The Role of Strain by Cardiac Magnetic Resonance Imaging in Predicting the Prognosis of Patients with Chronic Thromboembolic Pulmonary Hypertension.Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors.

Ruilin QuanDepartment of Pulmonary Vascular Disease, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Disease, Chinese Academy of Medical Sciences and Peking Union Medical College, No. 167, Beilishi Road, Xicheng District, Beijing, 100037, China.
Yuanhua YangRespiratory and Critical Care Medicine, Beijing Institute of Respiratory Medicine, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, 100043, China.
Zhenwen YangCardiovascular, Tianjin Medical University General Hospital, Tianjin, 300052, China.
Hongyan TianPeripheral Vascular Department of First Affiliated Hospital, Medical College of Xi'an Jiaotong University, Xi'an, 710061, China.
Shengqing LiDepartment of Respiratory Medicine, Xijing Hospital, Fourth Military Medical University, Xi'an, 710032, China.
Jieyan ShenRenji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, 200240, China.
Yingqun JiDepartment of Respiratory, First Affiliated Hospital of Dalian Medical University, Dalian, 116011, China.
Gangcheng ZhangDepartment of Cardiology, Wuhan Asia Heart Hospital, Wuhan, 430022, China.
Caojin ZhangDepartment of Cardiology, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, 510080, China.
Guangyi WangChinese PLA General Hospital, Medical School of Chinese PLA, Beijing, 100039, China.
Yuhao LiuHeart Center of Henan Provincial People's Hospital, Central China Fuwai Hospital, Central China Fuwai Hospital of Zhengzhou University, Zhengzhou, 450003, China.
Zhaozhong ChengRespiratory Department, The Affiliated Hospital of Qingdao University, Qingdao, 266000, China.
Zaixin YuDepartment of Cardiology, Xiangya Hospital, Central South University, Changsha, 410008, China.
Zhiyuan SongDepartment of Cardiology, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, 400038, China.
Zeqi ZhengDepartment of Cardiology, The First Affiliated Hospital of Nanchang University, Nanchang, 330006, China.
Wei CuiDepartment of Cardiology, Second Hospital of Hebei Medical University, Shijiazhuang, 050000, China.
Yucheng ChenDepartment of Cardiology, West China Hospital, Sichuan University, Chengdu, 610041, China.
Shuang LiuBeijing Anzhen Hospital, Capital Medical University, Beijing, 100029, China.
Xiaoxi ChenDepartment of Pulmonary Vascular Disease, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Disease, Chinese Academy of Medical Sciences and Peking Union Medical College, No. 167, Beilishi Road, Xicheng District, Beijing, 100037, China.
Yuling QianDepartment of Pulmonary Vascular Disease, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Disease, Chinese Academy of Medical Sciences and Peking Union Medical College, No. 167, Beilishi Road, Xicheng District, Beijing, 100037, China.
Changming XiongDepartment of Pulmonary Vascular Disease, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Disease, Chinese Academy of Medical Sciences and Peking Union Medical College, No. 167, Beilishi Road, Xicheng District, Beijing, 100037, China.
Guangliang ShanInstitute of Basic Medical Sciences, Chinese Academy of Medical Sciences, Beijing, 100037, China.
Jianguo HeDepartment of Pulmonary Vascular Disease, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Disease, Chinese Academy of Medical Sciences and Peking Union Medical College, No. 167, Beilishi Road, Xicheng District, Beijing, 100037, China. hejianguofw@163.com.ORCID http://orcid.org/0000-0003-0521-895X

Funding

Key Technologies Research and Development Program 2011BAI11B15National Key Research and Development Program of China 2016YFC1304400
6 · The paper itself

Abstract

backgroundAt present, there is no generally accepted comprehensive prognostic risk prediction model for medically treated chronic thromboembolic pulmonary hypertension (CTEPH) patients.

methodsConsecutive medically treated CTEPH patients were enrolled in a national multicenter prospective registry study from August 2009 to July 2018. A multivariable Cox proportional hazards model was utilized to derive the prognostic model, and a simplified risk score was created thereafter. Model performance was evaluated in terms of discrimination and calibration, and compared to the Swedish/COMPERA risk stratification method. Internal and external validation were conducted to validate the model performance.

resultsA total of 432 patients were enrolled. During a median follow-up time of 38.73 months (IQR: 20.79, 66.10), 94 patients (21.8%) died. The 1-, 3-, and 5-year survival estimates were 95.5%, 83.7%, and 70.9%, respectively. The final model included the following variables: the Swedish/COMPERA risk stratum (low-, intermediate- or high-risk stratum), pulmonary vascular resistance (PVR, ≤ or > 1600 dyn·s/cm

conclusionsA novel risk stratification strategy can serve as a useful tool for determining prognosis and guide management for medically treated CTEPH patients.

trial registrationClinicalTrials.gov (Identifier: NCT01417338).

Indexed as

AdultAgedChinaFemaleHumansHypertension, PulmonaryMaleMiddle AgedPractice Guidelines as TopicPrognosisProspective StudiesRegistriesRenal Insufficiency, ChronicRisk AssessmentSurvival AnalysisVascular ResistanceChronic thromboembolic pulmonary hypertensionPrognosisRisk stratification

Identifiers

PMID33879094
PMCPMC8056726

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.