Evidence map›Paper›PMID 33879044›Full record

ArticleBMC cardiovascular disorders2021

The association between homocysteine levels and cardiovascular disease risk among middle-aged and elderly adults in Taiwan.

Chin-Chuan Shih, Yu-Lin Shih, Jau-Yuan Chen

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC cardiovascular disorders, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 1 pooled it
5.3field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 1 synthesis or guideline pooled it, 39 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Chin-Chuan ShihGeneral Administrative Department, United Safety Medical Group, 2F, No.302, Zhongzheng Rd., Xinzhuang District, New Taipei City, 242, Taiwan (R.O.C.).
Yu-Lin ShihDepartment of Family Medicine, Chang-Gung Memorial Hospital, Linkou Branch, No.5, Fuxing St., Guishan Dist, Taoyuan City, 333, Taiwan (R.O.C.).
Jau-Yuan ChenDepartment of Family Medicine, Chang-Gung Memorial Hospital, Linkou Branch, No.5, Fuxing St., Guishan Dist, Taoyuan City, 333, Taiwan (R.O.C.). welins@cgmh.org.tw.ORCID 0000-0001-9195-7833
Chang Gung Memorial Hospital · TWChang Gung University of Science and Technology · TW

Funding

United Safety Medical Group USGN2019001
6 · The paper itself

Abstract

backgroundOur study aimed to determine the association between homocysteine levels and cardiovascular disease (CVD) risk in middle-aged and elderly adults in a community in northern Taiwan.

methodsParticipants in our study included adults aged 50 to 85 years old during community health examinations in 2019. A total of 396 people were enrolled, the ethnicity of all participants is Chinese. We divided participants according to tertiles of ln[homocysteine] level (low, middle and high groups). The CVD risk was calculated by the Framingham cardiovascular risk score (FRS). An FRS ≥ 20% indicated high CVD risk. Pearson correlation coefficients were calculated between homocysteine level and other cardio-metabolic risk factors while adjusting for age. Multivariate logistic regression analysis was used to determine the association of high and middle ln[homocysteine] groups with high CVD risk after adjusting age, sex, uric acid, creatinine, and body mass index (BMI). The Youden index and receiver operating characteristic (ROC) curves were performed to determine the optimized cut-off value.

resultsThere were 396 people enrolled for analysis; 41.4% of participants were male, and the average age was 64.79 (± 8.76). In our study, we showed a positive correlation of homocysteine with FRS. In the logistic regression models, higher ln[homocysteine] levels was associated with higher CVD risk with a odds ratio (OR) of 2.499 and 95% confidence interval (CI) of 1.214 to 5.142 in the high homocysteine level group compared with the low homocysteine group after adjusting for traditional CVD risk factors. The area under the ROC curve was 0.667, and a ln[homocysteine] cut-off value of 2.495 µmol/L was determined.

conclusionsMiddle-aged and elderly people with increased homocysteine levels were associated with higher FRSs in this Taiwan community. Furthermore, homocysteine was an independent risk factor for high CVD risk in this study.

Indexed as

AgedAged, 80 and overAge FactorsBiomarkersCardiovascular DiseasesCross-Sectional StudiesFemaleHeart Disease Risk FactorsHomocysteineHumansHyperhomocysteinemiaMaleMiddle AgedPrognosisRisk AssessmentTaiwanBiomarkersHomocysteineCardiovascular diseaseFramingham risk scoreHomocysteineMiddle-aged and elderly

Identifiers

PMID33879044
PMCPMC8056530
OpenAlexW3112475357

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LicenceCC BY
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.