ArticleJournal of sport and health science2021
Adverse associations of sedentary behavior with cancer incidence and all-cause mortality: A prospective cohort study.
Article in Journal of sport and health science, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
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Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Sedentary behavior and cancer-an umbrella review and meta-analysis.European journal of epidemiology · 2022Pooled it
- The effectiveness of a 6-month intervention with sit-stand workstation in office workers: Results from the SUFHA cluster randomized controlled trial.Work (Reading, Mass.) · 2024Trial
- Device-measured movement behaviours and cancer incidence in a population sample of UK adults: Dual 24-hour analyses of postural and intensity compositions.BMC medicine · 2026Article
- Bidirectional reallocations of sitting time, physical activity, and sleep in relation to risk of all-cause mortality and cardiovascular disease: An analysis of the Prospective Urban Rural Epidemiology (PURE)-China cohort study.Journal of sport and health science · 2026Article
- The association of lifestyle with cardiovascular and all-cause mortality based on machine learning: a prospective study from the NHANES.BMC public health · 2025Article
- Atherosclerotic Cardiovascular Disease in Cancer Survivors: Current Evidence, Risk Prediction, Prevention, and Management.Journal of lipid and atherosclerosis · 2025Review
- Sedentary behavior mediates the association between weight-adjusted waist index and cardiovascular disease in patients with diabetes.PloS one · 2025Article
- Designing a Dyad-Based Digital Health Intervention to Reduce Sedentary Time in Black Breast Cancer Survivors and Their First-degree Relatives: Human-Centered Design Study.JMIR formative research · 2023Article
- Building a case for incorporating sport as an indicator in human development index.Sport sciences for health · 2023Article
- The association between physical performance and subjective wellbeing in Chinese older adults: A cross-sectional study.Frontiers in public health · 2022Article
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20 authors.
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Abstract
backgroundInconsistent results have been reported in developed countries for relationships between sedentary behavior and cancer incidence and mortality, and evidence from the Chinese population is scarce. This study aimed to investigate such relationships in large Chinese population-based prospective cohorts and to explore the joint effect and interaction of sedentary behavior and moderate-to-vigorous physical activity (MVPA) on these relationships.
methodsWe included 95,319 Chinese adults without cancer from 3 large cohorts and assessed their sedentary behavior and physical activity with a unified questionnaire. Cancer incidence and mortality were confirmed by interviewing participants or their proxies and checking hospital records and death certificates. Hazard ratios (HRs) and 95% confidence intervals (95%CIs) for cancer and mortality were estimated using Cox proportional hazards regression models.
resultsDuring 559,002 person-years of follow-up, 2388 cancer events, 1571 cancer deaths, and 4562 all-cause deaths were recorded. Sedentary behavior was associated with increased risk of developing cancer and deaths in a dose-response manner. The multivariable-adjusted HRs (95%CIs) were the following: HR = 1.16, 95%CI: 1.01‒1.33; HR = 1.24, 95%CI: 1.04‒1.48; and HR = 1.15, 95%CI: 1.04‒1.28 for cancer incidence, cancer mortality, and all-cause mortality, respectively, for those having ≥10 h/day of sedentary time compared with those having <6 h/day of sedentary time. Sedentary populations (≥10 h/day) developed cancer or died 4.09 years and 2.79 years earlier, respectively, at the index age of 50 years. Failure to achieve the recommended level of MVPA may further aggravate the adverse associations, with the highest cancer and mortality risks being observed among participants with both ≥10 h/day of sedentary time and <150 min/week of MVPA. Limitations of this study include the fact that physical activity information was obtained via questionnaire instead of objective measurement and that there were insufficient incident cases for the analysis of associations between sedentary behavior and site-specific cancers.
conclusionSedentary behavior was associated with an increased risk of cancer and all-cause mortality among Chinese adults, especially for those with ≥10 h/day of sedentary time. It is necessary to reduce sedentary time, in addition to increasing MVPA levels, for the prevention of cancer and premature death.
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