Evidence map›Paper›PMID 33878377›Full record

ArticleNeuroImage2021

A 16-year study of longitudinal volumetric brain development in males with autism.

Molly B D Prigge, Nicholas Lange, Erin D Bigler, Jace B King, Douglas C Dean, Nagesh Adluru, Andrew L Alexander, Janet E Lainhart, Brandon A Zielinski

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in NeuroImage, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed, 2 pooled it
4.3field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 2 syntheses or guidelines pooled it, 58 citations in OpenAlex.

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  17. Retinal Thinning in Adults with Autism Spectrum Disorder.Journal of autism and developmental disorders · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Molly B D PriggeDepartment of Radiology and Imaging Sciences, University of Utah, Salt Lake City, UT, USA. Electronic address: molly.prigge@hsc.utah.edu.
Nicholas LangeDepartment of Psychiatry, Harvard School of Medicine, Boston, MA, USA.
Erin D BiglerDepartment of Psychology and Neuroscience Center, Brigham Young University, Provo, UT, USA; Department of Neurology, University of Utah, Salt Lake City, UT USA; Department of Psychiatry, University of Utah, Salt Lake City, UT USA; Department of Neurology, University of California-Davis, Davis, CA USA.
Jace B KingDepartment of Radiology and Imaging Sciences, University of Utah, Salt Lake City, UT, USA.
Douglas C DeanWaisman Center, University of Wisconsin-Madison, Madison, WI, USA; Department of Pediatrics, University of Wisconsin-Madison, Madison, WI, USA; Department of Medical Physics, University of Wisconsin-Madison, Madison, WI, USA.
Nagesh AdluruWaisman Center, University of Wisconsin-Madison, Madison, WI, USA.
Andrew L AlexanderWaisman Center, University of Wisconsin-Madison, Madison, WI, USA; Department of Medical Physics, University of Wisconsin-Madison, Madison, WI, USA; Department of Psychiatry, University of Wisconsin-Madison, Madison, WI, USA.
Janet E LainhartWaisman Center, University of Wisconsin-Madison, Madison, WI, USA; Department of Psychiatry, University of Wisconsin-Madison, Madison, WI, USA.
Brandon A ZielinskiDepartment of Radiology and Imaging Sciences, University of Utah, Salt Lake City, UT, USA; Department of Neurology, University of Utah, Salt Lake City, UT USA; Department of Pediatrics, University of Utah, Salt Lake City, UT, USA.
University of Wisconsin–Madison · USUniversity of Utah · USBrigham Young University · USHarvard University · US

Funding

Utah Center for Clinical and Translational ScienceUL1TR002538 · NCATS · UNIVERSITY OF UTAH · PI HESS, RACHEL, MAJERSIK, JENNIFER JUHL · 2018 to 2022
$26.0M
Atypical Late Neurodevelopment in Autism: A Longitudinal MRI and DTI StudyR01MH080826 · NIMH · UNIVERSITY OF WISCONSIN-MADISON · PI LAINHART, JANET ELIZABETH · 2007 to 2020
$6.5M
Waisman Intellectual and Developmental Disabilities Research Center Down Syndrome RegistryU54HD090256 · NICHD · UNIVERSITY OF WISCONSIN-MADISON · PI POLLAK, SETH D · 2016 to 2020
$6.0M
Siemens MAGNETOM Prisma 3T MRI scannerS10OD018482 · OD · UNIVERSITY OF UTAH · PI PARKER, DENNIS L · 2015 to 2015
$1.2M
Brain Network Development in Normal and Autistic ChildrenK08MH100609 · NIMH · UNIVERSITY OF UTAH · PI ZIELINSKI, BRANDON A. · 2014 to 2017
$759k
NCATS NIH HHS UL1 TR002538NICHD NIH HHS U54 HD090256NIH HHS S10 OD018482NIMH NIH HHS K08 MH100609NIMH NIH HHS R01 MH080826
6 · The paper itself

Abstract

Autism spectrum disorder (ASD) is a neurodevelopmental disorder with unknown brain etiology. Our knowledge to date about structural brain development across the lifespan in ASD comes mainly from cross-sectional studies, thereby limiting our understanding of true age effects within individuals with the disorder that can only be gained through longitudinal research. The present study describes FreeSurfer-derived volumetric findings from a longitudinal dataset consisting of 607 T1-weighted magnetic resonance imaging (MRI) scans collected from 105 male individuals with ASD (349 MRIs) and 125 typically developing male controls (258 MRIs). Participants were six to forty-five years of age at their first scan, and were scanned up to 5 times over a period of 16 years (average inter-scan interval of 3.7 years). Atypical age-related volumetric trajectories in ASD included enlarged gray matter volume in early childhood that approached levels of the control group by late childhood, an age-related increase in ventricle volume resulting in enlarged ventricles by early adulthood and reduced corpus callosum age-related volumetric increase resulting in smaller corpus callosum volume in adulthood. Larger corpus callosum volume was related to a lower (better) ADOS score at the most recent study visit for the participants with ASD. These longitudinal findings expand our knowledge of volumetric brain-based abnormalities in males with ASD, and highlight the need to continue to examine brain structure across the lifespan and well into adulthood.

Indexed as

Autism Spectrum DisorderCerebral VentriclesCorpus CallosumGray MatterHuman DevelopmentAdolescentAdultChildHumansLongitudinal StudiesMagnetic Resonance ImagingMaleMiddle AgedYoung AdultAutism spectrum disorderBrain volumesCorpus callosumLongitudinal developmentMRIVentricles

Identifiers

PMID33878377
PMCPMC8489006
OpenAlexW3154802914

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.