ArticleNeuroImage2021
Early detection of Alzheimer's disease using creatine chemical exchange saturation transfer magnetic resonance imaging.
Article in NeuroImage, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 46 citations in OpenAlex.
- An Interpretable Deep-Learning Approach for Efficient CEST Parameter Quantification: Importance-Ranked Saturation Transfer MRI Protocol.Magnetic resonance in medicine · 2026Article
- CEST MRI Processing Pipeline in Pilot Study of Alzheimer's Disease Patients.Magnetic resonance in medicine · 2026Article
- Multimodal MRI Reveals Cerebral and Vascular Amyloid-Driven Myeloarchitectural Disorganization in a Mouse Model of Alzheimer's Disease.NMR in biomedicine · 2026Article
- Mamba-AE: pixel-wise anomaly detection auto-encoder in chemical exchange saturation transfer magnetic resonance imaging.Quantitative imaging in medicine and surgery · 2026Article
- Denoising Low-Power CEST Imaging Using a Deep Learning Approach With a Dual-Power Feature Preparation Strategy.Magnetic resonance in medicine · 2026Article
- Chemical exchange saturation transfer MRI for neurodegenerative diseases: An update on clinical and preclinical studies.Neural regeneration research · 2026Article
- Neurovascular and metabolic dysfunction with cell type-specific transcriptomic changes in presymptomatic 5XFAD mice.Fluids and barriers of the CNS · 2026Article
- Creatine-weighted imaging in patients with Parkinson's disease.NPJ Parkinson's disease · 2025Article
- Chemical Exchange Saturation Transfer Imaging in Neuroinflammation: Methods, Challenges, and Recommendations.International journal of molecular sciences · 2025Review
- Cell type-specific contributions to impaired blood-brain barrier and cerebral metabolism in presymptomatic 5XFAD mice.bioRxiv : the preprint server for biology · 2025Article
- Brain temperature mapping based on chemical exchange saturation transfer signal at 2 ppm.Quantitative imaging in medicine and surgery · 2025Article
- Single-shot multiparametric MRI for separatingTheranostics · 2025Article
- Elucidating metabolite and pH variations in stroke through guanidino, amine and amide CEST MRI: A comparative multi-field study at 9.4T and 3T.NeuroImage · 2025Article
- Improving standardization and accuracy of in vivo omega plot exchange parameter determination using rotating-frame model-based fitting of quasi-steady-state Z-spectra.Magnetic resonance in medicine · 2025Article
- Multiparametric Chemical Exchange Saturation Transfer MRI Detects Metabolic Changes in Mild Cognitive Impairment Cases at 3.0 Tesla.Neurochemical research · 2024Article
- Unraveling contributions to the Z-spectrum signal at 3.5 ppm of human brain tumors.Magnetic resonance in medicine · 2024Article
- Fast quantitative MRI: Spiral Acquisition Matching-Based Algorithm (SAMBA) for Robust TJournal of magnetic resonance open · 2024Article
- Analytical solution of the Bloch-McConnell equations for steady-state CEST Z-spectra.Magnetic resonance imaging · 2024Article
- Preclinical Application of CEST MRI to Detect Early and Regional Tumor Response to Local Brain Tumor Treatment.Pharmaceutics · 2024Article
- Estimating the synaptic density deficit in Alzheimer's disease using multi-contrast CEST imaging.PloS one · 2024Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
Abstract
Detecting Alzheimer's disease (AD) at an early stage brings a lot of benefits including disease management and actions to slow the progression of the disease. Here, we demonstrate that reduced creatine chemical exchange saturation transfer (CrCEST) contrast has the potential to serve as a new biomarker for early detection of AD. The results on wild type (WT) mice and two age-matched AD models, namely tauopathy (Tau) and Aβ amyloidosis (APP), indicated that CrCEST contrasts of the cortex and corpus callosum in the APP and Tau mice were significantly reduced compared to WT counterpart at an early stage (6-7 months) (p < 0.011). Two main causes of the reduced CrCEST contrast, i.e. cerebral pH and creatine concentration, were investigated. From phantom and hypercapnia experiments, CrCEST showed excellent sensitivity to pH variations. From MRS results, the creatine concentration in WT and AD mouse brain was equivalent, which suggests that the reduced CrCEST contrast was dominated by cerebral pH change involved in the progression of AD. Immunohistochemical analysis revealed that the abnormal cerebral pH in AD mice may relate to neuroinflammation, a known factor that can cause pH reduction.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.