ArticlePreventive medicine2021
Multifaceted strategies for the control of COVID-19 outbreaks in long-term care facilities in Ontario, Canada.
Article in Preventive medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 2 of them syntheses that pooled it.
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Who cites it
27 citing papers in PubMed, 2 syntheses or guidelines pooled it, 61 citations in OpenAlex.
- Predictive models for health outcomes due to SARS-CoV-2, including the effect of vaccination: a systematic review.Systematic reviews · 2024Pooled it
- Non-pharmacological measures implemented in the setting of long-term care facilities to prevent SARS-CoV-2 infections and their consequences: a rapid review.The Cochrane database of systematic reviews · 2021Pooled it
- Economic Analyses of COVID-19 Interventions: A Narrative Review of Global Evidence.Healthcare (Basel, Switzerland) · 2025Review
- Identifying models of care to support residents in long-term care homes (LTCHs) both during and beyond COVID-19.PloS one · 2025Article
- A model-based assessment of social isolation practices for COVID-19 outbreak response in residential care facilities.BMC infectious diseases · 2024Article
- Comparing multiple infection control measures in a nursing home setting: a simulation study.Infection control and hospital epidemiology · 2024Article
- Implementation of the Dementia Isolation Toolkit in long-term care improves awareness but does not reduce moral distress amongst healthcare providers.BMC health services research · 2024Article
- Article
- The Perpetual Pivot: Understanding Care Partner Experiences in Ontario Long-Term Care Homes during the COVID-19 Pandemic.Geriatrics (Basel, Switzerland) · 2023Article
- Assessment of COVID-19 outbreaks in long-term care facilities.The Journal of hospital infection · 2023Article
- A Molecular and Epidemiological Investigation of a Large SARS-CoV-2 Outbreak in a Long-Term Care Facility in Luxembourg, 2021.Geriatrics (Basel, Switzerland) · 2023Article
- Article
- Economic evaluation of COVID-19 rapid antigen screening programs in the workplace.BMC medicine · 2022Article
- Using simulation modelling and systems science to help contain COVID-19: A systematic review.Systems research and behavioral science · 2022Article
- Testing and vaccination to reduce the impact of COVID-19 in nursing homes: an agent-based approach.BMC infectious diseases · 2022Article
- RT-qPCR-based tests for SARS-CoV-2 detection in pooled saliva samples for massive population screening to monitor epidemics.Scientific reports · 2022Article
- Agent-based epidemiological modeling of COVID-19 in localized environments.Computers in biology and medicine · 2022Article
- Impact of non-pharmaceutical interventions on SARS-CoV-2 outbreaks in English care homes: a modelling study.BMC infectious diseases · 2022Article
- COVID-19 Mental Health Stressors of Health Care Providers in the Pandemic Acceptance and Commitment to Empowerment Response (PACER) Intervention: Qualitative Study.JMIR formative research · 2022Article
- Examining the association between reported COVID-19 symptoms and testing for COVID-19 in Canada: a cross-sectional survey.BMJ open · 2022Article
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Authors and funding
9 authors at 6 institutions in 3 countries.
Funding
Abstract
The novel coronavirus disease 2019 (COVID-19) has caused severe outbreaks in Canadian long-term care facilities (LTCFs). In Canada, over 80% of COVID-19 deaths during the first pandemic wave occurred in LTCFs. We sought to evaluate the effect of mitigation measures in LTCFs including frequent testing of staff, and vaccination of staff and residents. We developed an agent-based transmission model and parameterized it with disease-specific estimates, temporal sensitivity of nasopharyngeal and saliva testing, results of vaccine efficacy trials, and data from initial COVID-19 outbreaks in LTCFs in Ontario, Canada. Characteristics of staff and residents, including contact patterns, were integrated into the model with age-dependent risk of hospitalization and death. Estimates of infection and outcomes were obtained and 95% credible intervals were generated using a bias-corrected and accelerated bootstrap method. Weekly routine testing of staff with 2-day turnaround time reduced infections among residents by at least 25.9% (95% CrI: 23.3%-28.3%), compared to baseline measures of mask-wearing, symptom screening, and staff cohorting alone. A similar reduction of hospitalizations and deaths was achieved in residents. Vaccination averted 2-4 times more infections in both staff and residents as compared to routine testing, and markedly reduced hospitalizations and deaths among residents by 95.9% (95% CrI: 95.4%-96.3%) and 95.8% (95% CrI: 95.5%-96.1%), respectively, over 200 days from the start of vaccination. Vaccination could have a substantial impact on mitigating disease burden among residents, but may not eliminate the need for other measures before population-level control of COVID-19 is achieved.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.