Evidence map›Paper›PMID 33878343›Full record

ArticleChest2021

Survival and Lung Transplant Outcomes for Individuals With Advanced Cystic Fibrosis Lung Disease Living in the United States and Canada: An Analysis of National Registries.

Kathleen J Ramos, Jenna Sykes, Sanja Stanojevic, Xiayi Ma, Joshua S Ostrenga, Aliza Fink, Bradley S Quon, Bruce C Marshall, Albert Faro, Kristofer Petren and 3 more

Abstract read
In one paragraph

Article in Chest, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Linkage of the CF Foundation Patient Registry with the Scientific Registry of Transplant Recipients database.Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society · 2025
    Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Article
  12. Survival difference between high-risk and low-risk CFTR genotypes after lung transplant.The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation · 2022
    Article
  13. Article
  14. Low body mass index as a barrier to lung transplant in cystic fibrosis.Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society · 2022
    Article
  15. A Framework for Using Real-World Data and Health Outcomes Modeling to Evaluate Machine Learning-Based Risk Prediction Models.Value in health : the journal of the International Society for Pharmacoeconomics and Outcomes Research · 2022
    Article
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Kathleen J RamosDivision of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, University of Washington, Seattle, WA. Electronic address: ramoskj@uw.edu.
Jenna SykesDivision of Respirology, St. Michael's Hospital, Toronto, ON, Canada.
Sanja StanojevicTranslational Medicine, Hospital for Sick Children, Toronto, ON, Canada.
Xiayi MaDivision of Respirology, St. Michael's Hospital, Toronto, ON, Canada.
Joshua S OstrengaCystic Fibrosis Foundation, Bethesda, MD.
Aliza FinkCystic Fibrosis Foundation, Bethesda, MD.
Bradley S QuonDivision of Respirology, Department of Medicine, University of British Columbia, Vancouver, BC, Canada.
Bruce C MarshallCystic Fibrosis Foundation, Bethesda, MD.
Albert FaroCystic Fibrosis Foundation, Bethesda, MD.
Kristofer PetrenCystic Fibrosis Foundation, Bethesda, MD.
Alexander ElbertCystic Fibrosis Foundation, Bethesda, MD.
Christopher H GossDivision of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, University of Washington, Seattle, WA; Division of Pulmonary and Sleep Medicine, Department of Pediatrics, University of Washington, Seattle, WA.
Anne L StephensonDivision of Respirology, St. Michael's Hospital, Toronto, ON, Canada; Keenan Research Centre, Li Ka Shing Knowledge Institute of St. Michael's Hospital, Toronto, ON, Canada; Institute of Health Policy, Management and Evaluation, University of Toronto, Toronto, ON, Canada.

Funding

Institute of Translational Health SciencesUL1TR000423 · NCATS · UNIVERSITY OF WASHINGTON · PI DISIS, MARY L. · 2012 to 2016
$49.4M
Translational Research Center to Expedite Novel Therapies in Cystic FibrosisP30DK089507 · NIDDK · SEATTLE CHILDREN'S HOSPITAL · PI PRADEEP k SINGH · 2010 to 2026
$21.4M
Proof of Principle Evaluation of IV Gallium Nitrate in Patients with CFUM1HL119073 · NHLBI · UNIVERSITY OF WASHINGTON · PI GOSS, CHRISTOPHER HOOPER, SINGH, PRADEEP K · 2013 to 2017
$4.8M
OPTIMIZE - DCCU01HL114589 · NHLBI · SEATTLE CHILDREN'S HOSPITAL · PI HAMBLETT, NICOLE MAYER · 2013 to 2017
$3.3M
A Phase 1b, Multi-center Study of IV Gallium Nitrate in Patients with Cystic Fibrosis who are colonized with Nontuberculosis Mycobacterium (The ABATE Study).R01FD006848 · FDA · SEATTLE CHILDREN'S HOSPITAL · PI Christopher Hooper Goss, JERRY A NICK · 2020 to 2026
$3.1M
Phase 2 Study of Intravenous Gallium Nitrate in the Treatment of Cystic FibrosisR01FD003704 · FDA · UNIVERSITY OF WASHINGTON · PI GOSS, CHRISTOPHER HOOPER · 2009 to 2018
$2.0M
Predicting survival and planning for lung transplantation in severe cystic fibrosisK23HL138154 · NHLBI · UNIVERSITY OF WASHINGTON · PI RAMOS, KATHLEEN JESSICA · 2017 to 2021
$947k
FDA HHS R01 FD003704FDA HHS R01 FD006848NCATS NIH HHS UL1 TR000423NHLBI NIH HHS K23 HL138154NHLBI NIH HHS U01 HL114589NHLBI NIH HHS UM1 HL119073NIDDK NIH HHS P30 DK089507
6 · The paper itself

Abstract

backgroundUnderstanding how health outcomes differ for patients with advanced cystic fibrosis (CF) lung disease living in the United States compared with Canada has health policy implications. RESEARCH QUESTION: What are rates of lung transplant (LTx) and rates of death without LTx in the United States and Canada among individuals with FEV STUDY DESIGN AND

methodsThis was a retrospective population-based cohort study, 2005 to 2016, using the US CF Foundation, United Network for Organ Sharing, and Canadian CF registries. Individuals with CF and at least two FEV

resultsThere were 5,899 patients (53% male) and 905 patients (54% male) with CF with FEV

interpretationThere are lower rates of LTx and an increased risk of death without LTx for US patients with CF with FEV

Indexed as

Cystic FibrosisLung TransplantationRespiratory Function TestsAdultCanadaChildDisease ProgressionFemaleHealth PolicyHealth Services MisuseHumansInsurance Claim ReviewMaleMortalityNeeds AssessmentRegistriesaccess to transplantationadvanced lung diseasecystic fibrosislung transplantation

Identifiers

PMID33878343
PMCPMC8449008

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.