Evidence map›Paper›PMID 33877964›Full record

ArticleeLife2021

Nutrient dominance governs the assembly of microbial communities in mixed nutrient environments.

Sylvie Estrela, Alicia Sanchez-Gorostiaga, Jean Cc Vila, Alvaro Sanchez

Open access · goldAbstract read
In one paragraph

Article in eLife, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers.

0numbers the graph read from it
0cells of the map it votes in
53citing papers in PubMed
6.8field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

53 citing papers in PubMed, 103 citations in OpenAlex.

  1. Cross-feeding enables robust coexistence between four bacterial species.Proceedings of the National Academy of Sciences of the United States of America · 2026
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  5. Artificial soil (ArtSoil): Recreating soil conditions in synthetic plant growth media.The Plant journal : for cell and molecular biology · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 2 countries.

Sylvie Estrela *Department of Ecology & Evolutionary Biology and Microbial Sciences Institute, Yale University, New Haven, United States.ORCID 0000-0003-1946-3657
Alicia Sanchez-Gorostiaga *Department of Ecology & Evolutionary Biology and Microbial Sciences Institute, Yale University, New Haven, United States.ORCID 0000-0002-2719-5659
Jean Cc Vila *Department of Ecology & Evolutionary Biology and Microbial Sciences Institute, Yale University, New Haven, United States.ORCID 0000-0003-0499-0200
Alvaro SanchezDepartment of Ecology & Evolutionary Biology and Microbial Sciences Institute, Yale University, New Haven, United States.ORCID 0000-0002-2292-5608
Yale University · US

Funding

Predicting the assembly and function of microbial consortia: a systems biology approachR35GM133467 · NIGMS · YALE UNIVERSITY · PI SANCHEZ DE ANDRES, ALVARO · 2019 to 2021
$1.3M
NIGMS NIH HHS R35 GM133467NIH HHS 1R35 GM133467-01
6 · The paper itself

Abstract

A major open question in microbial community ecology is whether we can predict how the components of a diet collectively determine the taxonomic composition of microbial communities. Motivated by this challenge, we investigate whether communities assembled in pairs of nutrients can be predicted from those assembled in every single nutrient alone. We find that although the null, naturally additive model generally predicts well the family-level community composition, there exist systematic deviations from the additive predictions that reflect generic patterns of nutrient dominance at the family level. Pairs of more-similar nutrients (e.g. two sugars) are on average more additive than pairs of more dissimilar nutrients (one sugar-one organic acid). Furthermore, sugar-acid communities are generally more similar to the sugar than the acid community, which may be explained by family-level asymmetries in nutrient benefits. Overall, our results suggest that regularities in how nutrients interact may help predict community responses to dietary changes.

Indexed as

MicrobiotaAcidsBacteriaNutrientsOrganic ChemicalsSugarsAcidsNutrientsOrganic ChemicalsSugarscomputational biologyconsumer-resource modelsecologyenvironmental complexityMicrobial community assemblynutrient interactionsresource specializationsystems biology

Identifiers

PMID33877964
PMCPMC8057819
OpenAlexW3155064590

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.