ReviewNeurology and therapy2021
Comprehensive Approach to Management of Multiple Sclerosis: Addressing Invisible Symptoms-A Narrative Review.
Review in Neurology and therapy, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 61 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
61 citing papers in PubMed, 114 citations in OpenAlex.
- Association of neuropathic pain with bladder and bowel dysfunction, functional disability, and quality of life of patients with multiple sclerosis.Turkish journal of physical medicine and rehabilitation · 2026Article
- Understanding the Unmet Needs of People with MS at Diagnosis and Throughout Their Care Journey: Insights from a Survey-Based Study.Neurology and therapy · 2026Article
- Management of Lower Urinary Tract Symptoms in Patients With Multiple Sclerosis.Current urology reports · 2026Review
- Self-mastery buffers associations between stressful life events and mental quality of life and fatigue in people living with multiple sclerosis.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2026Article
- Implementing Co-innovation to Develop an Accessible, Web-Based Exercise Program for People with Multiple Sclerosis.Archives of rehabilitation research and clinical translation · 2026Article
- The relationship between objective and subjective cognitive performance and clinical and MRI disease burden in early multiple sclerosis.Scientific reports · 2026Article
- Employment status and self-rated health in people with multiple sclerosis in Sweden.BMC neurology · 2026Article
- Association between lower urinary tract symptoms on quality of life in women with multiple sclerosis: The mediating role of loneliness.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026Article
- Kinesiophobia in Multiple Sclerosis: Associations with Age, Anxiety, and Physical Activity.Medical science monitor : international medical journal of experimental and clinical research · 2026Article
- Observing life from the sideline - a qualitative study on experiences of living with pregnancy-related pelvic girdle pain.BMC pregnancy and childbirth · 2026Article
- Invisible symptoms and associated factors in multiple sclerosis patients.Journal of education and health promotion · 2026Article
- Simulation of Clinical Visits as a Novel Approach to Evaluate Digital Health in Multiple Sclerosis: Simulation Study.JMIR medical informatics · 2025Article
- Validation and Interpretation of the Persian Version of the Swallowing Disturbance Questionnaire in Patients with Multiple Sclerosis.NeuroSci · 2025Article
- Investigating the Associated Factors of Mood Disorders and Fatigue in Multiple Sclerosis Patients With Cognitive Impairment: A Cross-Sectional Study.Health science reports · 2025Article
- The importance of patient-reported outcomes: A call for their integration in the routine care of patients with multiple sclerosis.Multiple sclerosis (Houndmills, Basingstoke, England) · 2025Review
- Finnish Registry-Based Protocol for Screening and Management of Fatigue and Cognitive Problems in Multiple Sclerosis: Observational Study.JMIR human factors · 2025Observational
- Progressive multiple sclerosis: Evaluating current therapies and exploring future treatment strategies.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2025Review
- Identifying key determinants of work-related difficulties in multiple sclerosis: integrating clinical measures and socio-occupational factors.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025Article
- Support needs and preferences for people with multiple sclerosis: a rapid review protocol.BMJ open · 2025Article
- Motherhood and pregnancy concerns of Saudi females with multiple sclerosis in Riyadh city: A quantitative analysis.Neurosciences (Riyadh, Saudi Arabia) · 2025Article
1 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Multiple sclerosis (MS) is a chronic autoimmune inflammatory disease of the central nervous system, leading to neurodegeneration and manifesting as a variety of symptoms. These can include "invisible" symptoms, not externally evident to others, such as fatigue, mood disorders, cognitive impairments, pain, bladder/bowel dysfunction, sexual dysfunction, and vision changes. Invisible symptoms are highly prevalent in people living with MS, with multifactorial etiology and potential to impact the disease course. Patient experiences of these symptoms include both physical and psychosocial elements, which when unaddressed negatively influence many aspects of quality of life and perception of health. Despite the high impact on patient lives, gaps persist in awareness and management of these hidden symptoms. The healthcare provider and patient author experiences brought together here serve to raise the profile of invisible symptoms and review strategies for a team-based approach to comprehensive MS care. We summarize the current literature regarding the prevalence and etiology of invisible symptoms to convey the high likelihood that a person living with MS will contend with one or more of these concerns. We then explore how open communication between people living with MS and their care team, stigma mitigation, and shared decision-making are key to comprehensive management of invisible symptoms. We recommend validated screening tools and technological advancements that may be incorporated into MS care to regularly monitor these symptoms, offering insight into how healthcare providers can both educate and listen to patients, with the goal of improved patient quality of life. By pairing clinical knowledge with an understanding and consideration of the patient perspective, providers will be equipped to foster a patient-centered dialogue that encourages shared decision-making. Invisible symptoms of MS.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.