Evidence map›Paper›PMID 33876912›Full record

ReviewPuerto Rico health sciences journal2021

Association of Radiotherapy-Related Intestinal Injury and Cancer-related Fatigue: A Brief Review and Commentary.

Velda J Gonzalez-Mercado, Sara Marrero, Josué Pérez-Santiago, Maribel Tirado-Gómez, Miguel A Marrero-Falcón, Elsa Pedro, Leorey N Saligan

Open access · greenAbstract readReview
In one paragraph

Review in Puerto Rico health sciences journal, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.4field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 4 citations in OpenAlex.

  1. Proton FLASH Exposure Preserves Gut Commensal Microbiomes and Spares Intestinal Stem Cells.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  2. Article
  3. Review
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Velda J Gonzalez-MercadoAssistant Professor, New York University Rory Meyers, College of Nursing, NY, United States.
Sara MarreroCollege of Arts and Sciences, University of South Florida, Tampa, FL, United States.
Josué Pérez-SantiagoAssistant Professor of Computational Biology and Bioinformatics Director, Puerto Rico Omics Center Comprehensive Cancer Center, University of Puerto Rico San Juan, PR.
Maribel Tirado-GómezAssistant Professor of Medicine, Department of Hematology and Oncology, Medical Sciences Campus, University of Puerto Rico, San Juan, PR.
Miguel A Marrero-FalcónMedical Practitioner, Emergency Room Department, Bayamón Regional Hospital, Bayamón, PR.
Elsa PedroAssistant Professor, School of Pharmacy, Medical Sciences Campus, University of Puerto Rico, San Juan, PR.
Leorey N SaliganTenure-Track Investigator and Chief of Symptom Biology Unit NINR/NIH, Bethesda, MD, United States.
University of South Florida · US

Funding

UPR/MDACC Partnership for Excellence in Cancer Research(Parent Grant U54 CA096297)U54CA096297 · NCI · UNIVERSITY OF PUERTO RICO MED SCIENCES · PI SHARON Hermes GIORDANO, REYNOLD Eugenio LOPEZ-ENRIQUEZ · 2002 to 2026
$36.9M
UPR/MDACC Partnership for Excellence in Cancer Research (Luis Segarra supplement)U54CA096300 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI SHARON Hermes GIORDANO · 2002 to 2026
$23.8M
TECHNOLOGIES AND RESOURCES FOR CORE LABORATORIESU54MD007587 · NIMHD · UNIVERSITY OF PUERTO RICO MED SCIENCES · PI LUCIANO, CARLOS A., WOJNA, VALERIE · 2012 to 2018
$23.2M
Tracking and Evaluation CoreU54GM133807 · NIGMS · UNIVERSITY OF PUERTO RICO MED SCIENCES · PI BONILLA-FELIX, MELVIN · 2020 to 2024
$17.7M
Fatigue and the Gut Microbiome of Patients Receiving Chemoradiotherapy for Rectal CancerF32NR016618 · NINR · UNIVERSITY OF SOUTH FLORIDA · PI GONZALEZ-MERCADO, VELDA JANET · 2017 to 2019
$180k
NCI NIH HHS U54 CA096297NCI NIH HHS U54 CA096300NIGMS NIH HHS U54 GM133807NIMHD NIH HHS U54 MD007587NINR NIH HHS F32 NR016618
6 · The paper itself

Abstract

Radiotherapy treatment-induced intestinal injury and gut microbial perturbation/dysbiosis have been implicated in the pathobiology of cancer-related fatigue. The objective of this brief review was to explore the available evidence of the relationship between intestinal injury and self-reported fatigue, especially among cancer patients. The scientific evidence-including our own-linking gut mucosal barrier dysfunction and gut microbial perturbation/dysbiosis induced by cancer treatment with worsening of cancer related fatigue (perhaps through the gut-brain axis) is limited but promising. Emerging data suggest that lifestyle interventions and the administration of specific probiotics may favorably modulate the gut microbiota and potentially mediate beneficial effects leading to improvements in fatigue.

Indexed as

DysbiosisFatigueRadiation InjuriesBrain-Gut AxisHumansIntestinesNeoplasmsDysbiosisIntestinal injuryRadiotherapy-related fatigue

Identifiers

PMID33876912
PMCPMC9109698
OpenAlexW3153009162

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.