Evidence map›Paper›PMID 33876883›Full record

Trial reportStem cells translational medicine2021

Stem cells for bronchopulmonary dysplasia in preterm infants: A randomized controlled phase II trial.

So Yoon Ahn, Yun Sil Chang, Myung Hee Lee, Se In Sung, Byong Sop Lee, Ki Soo Kim, Ai-Rhan Kim, Won Soon Park

Open access · goldAbstract readClinical Trial, Phase IIRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Stem cells translational medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 73 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
73citing papers in PubMed, 5 pooled it
11.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

73 citing papers in PubMed, 5 syntheses or guidelines pooled it, 107 citations in OpenAlex.

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  16. The Developmental Origins of Asthma and COPD.Annual review of physiology · 2026
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13 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

So Yoon AhnDepartment of Pediatrics, Samsung Medical Center and Sungkyunkwan University School of Medicine, Seoul, South Korea.ORCID 0000-0002-1821-3173
Yun Sil ChangDepartment of Pediatrics, Samsung Medical Center and Sungkyunkwan University School of Medicine, Seoul, South Korea.
Myung Hee LeeStatistics and Data Center, Research Institute for Future Medicine, Samsung Medical Center, Seoul, South Korea.
Se In SungDepartment of Pediatrics, Samsung Medical Center and Sungkyunkwan University School of Medicine, Seoul, South Korea.
Byong Sop LeeDepartment of Pediatrics, Asan Medical Center, University of Ulsan, Seoul, South Korea.
Ki Soo KimDepartment of Pediatrics, Asan Medical Center, University of Ulsan, Seoul, South Korea.
Ai-Rhan KimDepartment of Pediatrics, Asan Medical Center, University of Ulsan, Seoul, South Korea.
Won Soon ParkDepartment of Pediatrics, Samsung Medical Center and Sungkyunkwan University School of Medicine, Seoul, South Korea.
Samsung Medical Center · KRAsan Medical Center · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We previously demonstrated the safety and feasibility of mesenchymal stem cell (MSC) transplantation for bronchopulmonary dysplasia (BPD) in preterm infants in a phase I clinical trial. We thus investigated the therapeutic efficacy of MSCs for BPD in premature infants. A phase II double-blind, randomized, placebo-controlled clinical trial was conducted on preterm infants at 23 to 28 gestational weeks (GW) receiving mechanical ventilator support with respiratory deterioration between postnatal days 5 and 14. Infants were stratified by 23 to 24 GW and 25 to 28 GW and randomly allocated (1:1) to receive stem cells (1 × 10

Indexed as

Bronchopulmonary DysplasiaMesenchymal Stem Cell TransplantationDouble-Blind MethodHumansInfantInfant, NewbornInfant, Prematurebronchopulmonary dysplasiacell transplantationmesenchymal stem cellspremature infants

Identifiers

PMID33876883
PMCPMC8284779
OpenAlexW3154375309

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.