Evidence map›Paper›PMID 33876770›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2021

Structural basis for

Alex J Vecchio, Sewwandi S Rathnayake, Robert M Stroud

Open access · hybridAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed
4.1field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 54 citations in OpenAlex.

  1. Review
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  9. "Design principles of a membrane-spanning ubiquitin ligase".bioRxiv : the preprint server for biology · 2025
    Article
  10. Article
  11. Computational and structural biotechnology journal · 2025
    Article
  12. Article
  13. Article
  14. Review
  15. Article
  16. The biology and pathogenicity ofMicrobiology and molecular biology reviews : MMBR · 2024
    Review
  17. Article
  18. Microorganisms · 2024
    Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Alex J VecchioDepartment of Biochemistry, University of Nebraska-Lincoln, Lincoln, NE 68588; avecchio@unl.edu stroud@msg.ucsf.edu.ORCID 0000-0002-4222-7874
Sewwandi S RathnayakeDepartment of Biochemistry, University of Nebraska-Lincoln, Lincoln, NE 68588.
Robert M StroudDepartment of Biochemistry and Biophysics, University of California, San Francisco, CA 94158 avecchio@unl.edu stroud@msg.ucsf.edu.ORCID 0000-0003-2083-5665
University of Nebraska–Lincoln · USUniversity of California, San Francisco · US

Funding

Targeted mass spectrometry approaches to understand CART processing and recepter interactionsP20GM113126 · NIGMS · UNIVERSITY OF NEBRASKA LINCOLN · PI GUO, JIANTAO · 2016 to 2025
$20.8M
STRUCTURE/FUNCTION OF PROTEINS AT MOLECULAR LEVELR01GM024485 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI STROUD, ROBERT M · 1985 to 2024
$7.5M
Structure and Assembly of Membrane Proteins at Tight JunctionsR35GM138368 · NIGMS · UNIVERSITY OF NEBRASKA LINCOLN · PI Alex J. Vecchio · 2020 to 2026
$3.1M
NIGMS NIH HHS P20 GM113126NIGMS NIH HHS R01 GM024485NIGMS NIH HHS R35 GM138368
6 · The paper itself

Abstract

The bacterium

Indexed as

AnimalsBinding SitesClaudin-4Clostridium perfringensEnterotoxinsHumansMolecular Docking SimulationProtein BindingSf9 CellsSpodopteraTight JunctionsClaudin-4Enterotoxinsclaudinenterotoxinmembrane proteintight junctionX-ray structure

Identifiers

PMID33876770
PMCPMC8053971
OpenAlexW3142778780

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.