Evidence map›Paper›PMID 33876769›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2021

Mechanosensitive remodeling of the bacterial flagellar motor is independent of direction of rotation.

Navish Wadhwa, Yuhai Tu, Howard C Berg

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Osmotic stress triggers fast and reversible PMF collapse inbioRxiv : the preprint server for biology · 2025
    Article
  7. Article
  8. Measuring Bacterial Flagellar Motor Dynamics via a Bead Assay.Methods in molecular biology (Clifton, N.J.) · 2025
    Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Review
  14. Article
  15. Review
  16. Article
  17. Article
  18. Article
  19. Bacterial motility: machinery and mechanisms.Nature reviews. Microbiology · 2022
    Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Navish WadhwaDepartment of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138; navish_wadhwa@fas.harvard.edu.ORCID 0000-0002-3514-5256
Yuhai TuT. J. Watson Research Center, IBM, Yorktown Heights, NY 10598.ORCID 0000-0002-4589-981X
Howard C BergDepartment of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138.

Funding

SENSORY TRANSDUCTION IN BACTERIAL CHEMOTAXISR01AI016478 · NIAID · HARVARD UNIVERSITY · PI BERG, HOWARD C · 1985 to 2019
$14.1M
Quantitative Modeling of Signal Transduction in Bacterial ChemotaxisR01GM081747 · NIGMS · IBM THOMAS J. WATSON RESEARCH CENTER · PI TU, YUHAI · 2007 to 2018
$2.6M
Molecular Mechanisms and Biochemical Circuits for Adaptation in Biological SystemsR35GM131734 · NIGMS · IBM THOMAS J. WATSON RESEARCH CENTER · PI TU, YUHAI · 2019 to 2024
$1.8M
Identifying the mechanisms of mechanosensing by the bacterial flagellar motor K99GM134124 · NIGMS · HARVARD UNIVERSITY · PI WADHWA, NAVISH · 2020 to 2021
$200k
NIAID NIH HHS R01 AI016478NIGMS NIH HHS K99 GM134124NIGMS NIH HHS R01 GM081747NIGMS NIH HHS R35 GM131734
6 · The paper itself

Abstract

Motility is important for the survival and dispersal of many bacteria, and it often plays a role during infections. Regulation of bacterial motility by chemical stimuli is well studied, but recent work has added a new dimension to the problem of motility control. The bidirectional flagellar motor of the bacterium

Indexed as

Mechanotransduction, CellularBacterial ProteinsEscherichia coliFlagellaModels, TheoreticalRotationBacterial ProteinsMotA protein, BacteriaMotB protein, Bacteriabacterial motilityEscherichia coliflagellar motormolecular motorsself-assembly

Identifiers

PMID33876769
PMCPMC8054018

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.