Evidence map›Paper›PMID 33876765›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2021

MrgprC11

Haley R Steele, Yanyan Xing, Yuyan Zhu, Henry B Hilley, Katy Lawson, Yeseul Nho, Taylor Niehoff, Liang Han

Open access · greenAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
2.7field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 24 citations in OpenAlex.

  1. A neuroimmune axis linking S100A8/9 to itch sensitization in both bullous pemphigoid and atopic dermatitis.JID innovations : skin science from molecules to population health · 2026
    Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. MrgprC11American journal of respiratory cell and molecular biology · 2025
    Article
  7. Article
  8. Regional Differences in Itch Transmission.The Journal of investigative dermatology · 2024
    Article
  9. Article
  10. Article
  11. Neuroimmune interactions in atopic and allergic contact dermatitis.The Journal of allergy and clinical immunology · 2023
    Review
  12. Article
  13. Review
  14. Critical Players and Therapeutic Targets in Chronic Itch.International journal of molecular sciences · 2022
    Review
  15. Article
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Haley R SteeleSchool of Biological Sciences, Georgia Institute of Technology, Atlanta, GA 30332.ORCID 0000-0002-2039-3097
Yanyan XingSchool of Biological Sciences, Georgia Institute of Technology, Atlanta, GA 30332.ORCID 0000-0002-8431-9902
Yuyan ZhuSchool of Biological Sciences, Georgia Institute of Technology, Atlanta, GA 30332.
Henry B HilleySchool of Biological Sciences, Georgia Institute of Technology, Atlanta, GA 30332.ORCID 0000-0003-1347-6836
Katy LawsonSchool of Biological Sciences, Georgia Institute of Technology, Atlanta, GA 30332.ORCID 0000-0002-9364-2410
Yeseul NhoSchool of Biological Sciences, Georgia Institute of Technology, Atlanta, GA 30332.
Taylor NiehoffSchool of Biological Sciences, Georgia Institute of Technology, Atlanta, GA 30332.
Liang HanSchool of Biological Sciences, Georgia Institute of Technology, Atlanta, GA 30332 lhan41@gatech.edu.ORCID 0000-0001-8674-6433
Georgia Institute of Technology · US

Funding

The function of MrgprC11+ vagal sensory neurons in the airwayR01HL141269 · NHLBI · GEORGIA INSTITUTE OF TECHNOLOGY · PI HAN, LIANG · 2018 to 2022
$1.9M
Molecular and Cellular Mechanisms of Itch SensationR00NS087088 · NINDS · GEORGIA INSTITUTE OF TECHNOLOGY · PI HAN, LIANG · 2016 to 2018
$739k
Molecular and Cellular Mechanisms of Itch SensationK99NS087088 · NINDS · JOHNS HOPKINS UNIVERSITY · PI HAN, LIANG · 2014 to 2015
$190k
NHLBI NIH HHS R01 HL141269NINDS NIH HHS K99 NS087088NINDS NIH HHS R00 NS087088
6 · The paper itself

Abstract

Itch arising from glabrous skin (palms and soles) has attracted limited attention within the field due to the lack of methodology. This is despite glabrous itch arising from many medical conditions such as plantar and palmar psoriasis, dyshidrosis, and cholestasis. Therefore, we developed a mouse glabrous skin behavioral assay to investigate the contribution of three previously identified pruriceptive neurons in glabrous skin itch. Our results show that MrgprA3

Indexed as

NociceptionAnimalsMechanotransduction, CellularMiceMice, Inbred C57BLPruritusReceptors, G-Protein-CoupledSensory Receptor CellsSkinTouch PerceptionMrgprx1 protein, mouseReceptors, G-Protein-Coupledglabrous skinitchMrgprs

Identifiers

PMID33876765
PMCPMC8053975
OpenAlexW3145601782

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.