Evidence map›Paper›PMID 33876764›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2021

Direct coordination of pterin to Fe

Shyam R Iyer, Kasper D Tidemand, Jeffrey T Babicz, Ariel B Jacobs, Leland B Gee, Lærke T Haahr, Yoshitaka Yoda, Masayuki Kurokuzu, Shinji Kitao, Makina Saito and 4 more

Open access · bronzeAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.6field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 15 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Structural analysis of the tetrahydrobiopterin glucosyltransferase PsBGluT from Pseudanabaena sp. Chao 1811.Acta crystallographica. Section F, Structural biology communications · 2025
    Article
  5. Chemical reviews · 2024
    Review
  6. Article
  7. Article
  8. Review
  9. Mechanisms of OBiochemistry · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 5 institutions in 3 countries.

Shyam R IyerDepartment of Chemistry, Stanford University, Stanford, CA 94305.
Kasper D TidemandDepartment of Chemistry, Technical University of Denmark, 2800 Kongens Lyngby, Denmark.
Jeffrey T BabiczDepartment of Chemistry, Stanford University, Stanford, CA 94305.
Ariel B JacobsDepartment of Chemistry, Stanford University, Stanford, CA 94305.
Leland B GeeDepartment of Chemistry, Stanford University, Stanford, CA 94305.
Lærke T HaahrDepartment of Chemistry, Technical University of Denmark, 2800 Kongens Lyngby, Denmark.
Yoshitaka YodaJapan Synchrotron Radiation Research Institute, Hyogo 679-5198, Japan.
Masayuki KurokuzuInstitute for Integrated Radiation and Nuclear Science, Kyoto University, Osaka 590-0494, Japan.
Shinji KitaoInstitute for Integrated Radiation and Nuclear Science, Kyoto University, Osaka 590-0494, Japan.
Makina SaitoInstitute for Integrated Radiation and Nuclear Science, Kyoto University, Osaka 590-0494, Japan.
Makoto SetoInstitute for Integrated Radiation and Nuclear Science, Kyoto University, Osaka 590-0494, Japan.
Hans E M ChristensenDepartment of Chemistry, Technical University of Denmark, 2800 Kongens Lyngby, Denmark.ORCID 0000-0002-9540-8679
Günther H J PetersDepartment of Chemistry, Technical University of Denmark, 2800 Kongens Lyngby, Denmark.ORCID 0000-0001-9754-2663
Edward I SolomonDepartment of Chemistry, Stanford University, Stanford, CA 94305; solomone@stanford.edu.ORCID 0000-0003-0291-3199
Stanford University · USKyoto University · JPTechnical University of Denmark · DKBioneer (Denmark) · DKJapan Synchrotron Radiation Research Institute · JP

Funding

SPECTROSCOPIC STUDIES OF NONHEME IRON ENZYMESR01GM040392 · NIGMS · STANFORD UNIVERSITY · PI SOLOMON, EDWARD I · 1988 to 2021
$8.6M
Spectroscopic Characterization of Oxygen Intermediates in Non-heme and Heme Iron EnzymesR35GM145202 · NIGMS · STANFORD UNIVERSITY · PI EDWARD I SOLOMON · 2022 to 2026
$2.0M
Electronic Structure of Heme Enzyme Intermediates from Resonant Inelastic X-ray Scattering and L-Edge X-ray Absorption SpectroscopyF32GM122194 · NIGMS · STANFORD UNIVERSITY · PI GEE, LELAND BRUCE · 2017 to 2020
$227k
NIGMS NIH HHS F32 GM122194NIGMS NIH HHS R01 GM040392NIGMS NIH HHS R35 GM145202
6 · The paper itself

Abstract

The pterin-dependent nonheme iron enzymes hydroxylate aromatic amino acids to perform the biosynthesis of neurotransmitters to maintain proper brain function. These enzymes activate oxygen using a pterin cofactor and an aromatic amino acid substrate bound to the Fe

Indexed as

HumansIronNeurotransmitter AgentsNuclear ProteinsOxygenPterinsTryptophanZinc Finger Protein Gli2GLI2 protein, humanIronNeurotransmitter AgentsNuclear ProteinsOxygenPterinsTryptophanZinc Finger Protein Gli2cofactor-dependent metalloenzymesneurotransmitter biosynthesisoxygen activation

Identifiers

PMID33876764
PMCPMC8053929
OpenAlexW3146533945

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.