Evidence map›Paper›PMID 33876755›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2021

Immune cells fold and damage fungal hyphae.

Judith M Bain, M Fernanda Alonso, Delma S Childers, Catriona A Walls, Kevin Mackenzie, Arnab Pradhan, Leanne E Lewis, Johanna Louw, Gabriela M Avelar, Daniel E Larcombe and 5 more

Open access · hybridAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed
2.7field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 48 citations in OpenAlex.

  1. Cascading damage toProceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  2. Phagosome maturation during fungal infection.Current opinion in microbiology · 2026
    Review
  3. Article
  4. Podosomes and Mechanical Force.Results and problems in cell differentiation · 2026
    Review
  5. Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. Microbiology and molecular biology reviews : MMBR · 2024
    Review
  11. Article
  12. Article
  13. Article
  14. Hyphae ofJournal of fungi (Basel, Switzerland) · 2023
    Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 2 institutions in 3 countries.

Judith M BainAberdeen Fungal Group, Institute of Medical Sciences, Foresterhill, AB25 2ZD Aberdeen, United Kingdom.ORCID 0000-0002-1060-0419
M Fernanda AlonsoAberdeen Fungal Group, Institute of Medical Sciences, Foresterhill, AB25 2ZD Aberdeen, United Kingdom.
Delma S ChildersAberdeen Fungal Group, Institute of Medical Sciences, Foresterhill, AB25 2ZD Aberdeen, United Kingdom.ORCID 0000-0003-2869-7332
Catriona A WallsAberdeen Fungal Group, Institute of Medical Sciences, Foresterhill, AB25 2ZD Aberdeen, United Kingdom.ORCID 0000-0002-5955-9330
Kevin MackenzieMicroscopy and Histology Facility, Institute of Medical Sciences, Foresterhill, AB25 2ZD Aberdeen, United Kingdom.ORCID 0000-0002-0041-5375
Arnab PradhanAberdeen Fungal Group, Institute of Medical Sciences, Foresterhill, AB25 2ZD Aberdeen, United Kingdom.ORCID 0000-0003-4328-3912
Leanne E LewisAberdeen Fungal Group, Institute of Medical Sciences, Foresterhill, AB25 2ZD Aberdeen, United Kingdom.
Johanna LouwAberdeen Fungal Group, Institute of Medical Sciences, Foresterhill, AB25 2ZD Aberdeen, United Kingdom.ORCID 0000-0002-2054-0173
Gabriela M AvelarAberdeen Fungal Group, Institute of Medical Sciences, Foresterhill, AB25 2ZD Aberdeen, United Kingdom.
Daniel E LarcombeAberdeen Fungal Group, Institute of Medical Sciences, Foresterhill, AB25 2ZD Aberdeen, United Kingdom.
Mihai G NeteaDepartment of Internal Medicine and Radboud Center for Infectious Diseases, Radboud University Medical Center, 6500HB Nijmegen, The Netherlands.
Neil A R GowAberdeen Fungal Group, Institute of Medical Sciences, Foresterhill, AB25 2ZD Aberdeen, United Kingdom.
Gordon D BrownAberdeen Fungal Group, Institute of Medical Sciences, Foresterhill, AB25 2ZD Aberdeen, United Kingdom.
Lars P ErwigAberdeen Fungal Group, Institute of Medical Sciences, Foresterhill, AB25 2ZD Aberdeen, United Kingdom.
Alistair J P BrownAberdeen Fungal Group, Institute of Medical Sciences, Foresterhill, AB25 2ZD Aberdeen, United Kingdom; a.j.p.brown@exeter.ac.uk.ORCID 0000-0003-1406-4251
University of Aberdeen · GBUniversity of Bonn · DE

Funding

Medical Research Council MR/M026663/1Medical Research Council MR/M026663/2Medical Research Council MR/N006364/1Medical Research Council MR/N006364/2Medical Research Council MR/V033417/1Wellcome Trust 102705/Z/13/Z
6 · The paper itself

Abstract

Innate immunity provides essential protection against life-threatening fungal infections. However, the outcomes of individual skirmishes between immune cells and fungal pathogens are not a foregone conclusion because some pathogens have evolved mechanisms to evade phagocytic recognition, engulfment, and killing. For example,

Indexed as

PhagocytosisActomyosinAMP-Activated Protein Kinase KinasesAnimalsCandida albicansCD18 AntigensCell Adhesion MoleculesCells, CulturedDectin-1HumansHyphaeLectins, C-TypeMacrophagesMiceProtein KinasesRAW 264.7 CellsActomyosinAMP-Activated Protein Kinase KinasesCD18 AntigensCell Adhesion MoleculesDectin-1Lectins, C-TypeProtein Kinasescytoskeletonfungal hyphaemacrophagesmechanical forcepodosomes

Identifiers

PMID33876755
PMCPMC8053999
OpenAlexW3151270291

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.