Evidence map›Paper›PMID 33876675›Full record

ArticleUrologia2022

Renal effect of severe hypoxia evaluated By NGAL measurements: An in vivo and in vitro study.

Emilio Sacco, Matteo Vittori, Pietro Manuel Ferraro, Paola Verde, Alessandro Scagliusi, Silvia Baroni, Valentina Masola, Maurizio Onisto, Maria Nicosia, PierFrancesco Bassi

RetractedOpen access · greenAbstract readRetracted Publication
PubMed Publisher
In one paragraph

Article in Urologia, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 96% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Emilio SaccoDepartment of Urology, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Università Cattolica del Sacro Cuore, Rome, Italy.ORCID https://orcid.org/0000-0003-4640-8354
Matteo VittoriDepartment of Urology, San Carlo di Nancy Hospital, Rome, Italy.
Pietro Manuel FerraroNephrology Department, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Università Cattolica del Sacro Cuore, Rome, Italy.
Paola VerdeItalian Air Force, Flight Experimental Center, Aerospace Medicine Department, Pratica di Mare, Italy.
Alessandro ScagliusiItalian Air Force, Flight Experimental Center, Aerospace Medicine Department, Pratica di Mare, Italy.
Silvia BaroniClinical Chemistry, Biochemistry and Molecular Biology, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Università Cattolica del Sacro Cuore, Rome, Italy.
Valentina MasolaRenal Unit, Department of Medicine, Integrated University Hospital of Verona, Verona, Veneto, Italy.
Maurizio OnistoDepartment of Biomedical Sciences, University of Padua, Padova, Veneto, Italy.
Maria NicosiaClinical Chemistry, Biochemistry and Molecular Biology, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Università Cattolica del Sacro Cuore, Rome, Italy.
PierFrancesco BassiDepartment of Urology, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Università Cattolica del Sacro Cuore, Rome, Italy.
Università Cattolica del Sacro Cuore · ITOspedale San Carlo · ITUniversity of Padua · ITUniversity of Verona · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo investigate possible renal damage in healthy men exposed to extreme hypobaric hypoxia, using urinary Neutrophil Gelatinase-Associated Lipocalin (NGAL) concentration as biomarker. The value of NGAL as a biomarker of proximal tubular cell damage under hypoxic conditions was also tested in vitro experiments.

methodsNGAL was assayed in a cohort of air cadets (

resultsIn the in vivo study, geometric means of urinary NGAL/Cr ratio measured 24 h after hypobaric hypoxia in the hypobaric chamber were significantly lower than baseline values (13.4 vs 25.9 ng/mg,

conclusionsExposure to hypobaric-hypoxic environments does not cause significant and irreversible renal tubular injury in vivo and in vitro, except than in a late stage. The hypoxic insult does not seem to be mirrored by an increase of urinary NGAL in healthy men nor of NGAL gene expression in HK-2 cell culture or secretion in the culture medium in the in vitro conditions reported in the present study.

Indexed as

Acute Kidney InjuryBiomarkersHumansHypoxiaKidneyLipocalin-2MaleBiomarkersLipocalin-2acute kidney injuryhypobaric hypoxiaischemic preconditioningNeutrophil gelatinase-associated lipocalinNGAL

Identifiers

PMID33876675
OpenAlexW3154400835

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.