Evidence map›Paper›PMID 33876404›Full record

ReviewPharmacological reports : PR2021

Functional approaches to the study of G-protein-coupled receptors in postmortem brain tissue: [

Rebeca Diez-Alarcia, Yuji Odagaki, Patricia Miranda-Azpiazu, Ane M Gabilondo, J Javier Meana, Itziar Muneta-Arrate

Erratum issuedAbstract readReview
PubMed Publisher
In one paragraph

Review in Pharmacological reports : PR, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.3field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
  3. [Methods in molecular biology (Clifton, N.J.) · 2023
    Article
  4. Characterization of dopamine DPharmacological reports : PR · 2021
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Rebeca Diez-AlarciaDepartment of Pharmacology, Centro de Investigación Biomédica en Red de Salud Mental, University of the Basque Country UPV/EHU CIBERSAM, 48940, Leioa, Bizkaia, Spain.ORCID http://orcid.org/0000-0002-0806-9825
Yuji OdagakiDepartment of Psychiatry, Faculty of Medicine, Saitama Medical University, 38 Morohongo Moroyama-machi, Iruma-gun, Saitama, 350-0495, Japan.ORCID http://orcid.org/0000-0002-1792-028X
Patricia Miranda-AzpiazuDepartment of Pharmacology, Centro de Investigación Biomédica en Red de Salud Mental, University of the Basque Country UPV/EHU CIBERSAM, 48940, Leioa, Bizkaia, Spain.ORCID http://orcid.org/0000-0002-8620-1772
Ane M GabilondoDepartment of Pharmacology, Centro de Investigación Biomédica en Red de Salud Mental, University of the Basque Country UPV/EHU CIBERSAM, 48940, Leioa, Bizkaia, Spain.ORCID http://orcid.org/0000-0002-1892-3861
J Javier MeanaDepartment of Pharmacology, Centro de Investigación Biomédica en Red de Salud Mental, University of the Basque Country UPV/EHU CIBERSAM, 48940, Leioa, Bizkaia, Spain.ORCID http://orcid.org/0000-0002-7913-6714
Itziar Muneta-ArrateDepartment of Pharmacology, Centro de Investigación Biomédica en Red de Salud Mental, University of the Basque Country UPV/EHU CIBERSAM, 48940, Leioa, Bizkaia, Spain. itziar.muneta@ehu.eus.ORCID http://orcid.org/0000-0003-4209-4765
University of the Basque Country · ESSaitama Medical University · JP

Funding

Eusko Jaurlaritza IT1211/19Eusko Jaurlaritza KK-2019/00049Spanish State Research Agency and EDR Funds SAF2017-88126R
6 · The paper itself

Abstract

G-protein-coupled receptors (GPCRs) have an enormous biochemical importance as they bind to diverse extracellular ligands and regulate a variety of physiological and pathological responses. G-protein activation measures the functional consequence of receptor occupancy at one of the earliest receptor-mediated events. Receptor coupling to G-proteins promotes the GDP/GTP exchange on Gα subunits. Thus, modulation of the binding of the poorly hydrolysable GTP analog [

Indexed as

AnimalsBiological AssayBrainGuanosine 5'-O-(3-Thiotriphosphate)HumansImmunoprecipitationReceptors, G-Protein-CoupledSignal TransductionGuanosine 5'-O-(3-Thiotriphosphate)Receptors, G-Protein-Coupled[35S]GTPγSBiased agonismG-proteinImmunoprecipitationNative tissueSPA

Identifiers

PMID33876404
OpenAlexW4205122652

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.