ArticleCell and tissue research2021
Hidden cell diversity in Placozoa: ultrastructural insights from Hoilungia hongkongensis.
Article in Cell and tissue research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 37 citations in OpenAlex.
- The evolutionary origins of synaptic proteins and their changing roles in different organisms across evolution.Nature reviews. Neuroscience · 2026Review
- Placozoan secretory cell types implicated in feeding, innate immunity and regulation of behavior.PloS one · 2025Article
- Coordinated cellular behavior regulated by epinephrine neurotransmitters in the nerveless placozoa.Nature communications · 2024Article
- Beauty in the beast - Placozoan biodiversity explored through molluscan predator genomics.Ecology and evolution · 2024Article
- Long-Term Culturing of Placozoans (Trichoplax and Hoilungia).Methods in molecular biology (Clifton, N.J.) · 2024Article
- Parallel evolution of gravity sensing.Frontiers in cell and developmental biology · 2024Article
- The ancestral architecture of the immune system in simplest animals.Frontiers in immunology · 2024Article
- Parallel Evolution of Transcription Factors in Basal Metazoans.Methods in molecular biology (Clifton, N.J.) · 2024Article
- Chemical cognition: chemoconnectomics and convergent evolution of integrative systems in animals.Animal cognition · 2023Article
- Transposon-derived transcription factors across metazoans.Frontiers in cell and developmental biology · 2023Article
- Amino acids integrate behaviors in nerveless placozoans.Frontiers in neuroscience · 2023Article
- Alternative neural systems: What is a neuron? (Ctenophores, sponges and placozoans).Frontiers in cell and developmental biology · 2022Article
- Expanding of Life Strategies in Placozoa: Insights From Long-Term Culturing ofFrontiers in cell and developmental biology · 2022Article
- Studying Placozoa WBR in the Simplest Metazoan Animal, Trichoplax adhaerens.Methods in molecular biology (Clifton, N.J.) · 2022Article
- Placozoan fiber cells: mediators of innate immunity and participants in wound healing.Scientific reports · 2021Article
- Evolution of glutamatergic signaling and synapses.Neuropharmacology · 2021Review
- Neural versus alternative integrative systems: molecular insights into origins of neurotransmitters.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2021Review
- Selective Advantages of Synapses in Evolution.Frontiers in cell and developmental biology · 2021Article
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Authors and funding
7 authors at 5 institutions in 4 countries.
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Abstract
From a morphological point of view, placozoans are among the most simple free-living animals. This enigmatic phylum is critical for our understanding of the evolution of animals and their cell types. Their millimeter-sized, disc-like bodies consist of only three cell layers that are shaped by roughly seven major cell types. Placozoans lack muscle cells and neurons but are able to move using their ciliated lower surface and take up food in a highly coordinated manner. Intriguingly, the genome of Trichoplax adhaerens, the founding member of the enigmatic phylum, has disclosed a surprising level of genetic complexity. Moreover, recent molecular and functional investigations have uncovered a much larger, so-far hidden cell-type diversity. Here, we have extended the microanatomical characterization of a recently described placozoan species-Hoilungia hongkongensis. In H. hongkongensis, we recognized the established canonical three-layered placozoan body plan but also came across several morphologically distinct and potentially novel cell types, among them novel gland cells and "shiny spheres"-bearing cells at the upper epithelium. Thus, the diversity of cell types in placozoans is indeed higher than anticipated.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.