ArticleInternational journal of colorectal disease2021
Crohn's disease: a population-based study of surgery in the age of biological therapy.
Article in International journal of colorectal disease, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 48 citations in OpenAlex.
- Trial
- Perioperative anti-α4β7 Integrin Blockade Alters Wound Cell Infiltrate but Not the Functional Outcome of Ileocecal Anastomoses in Mice With Crohn's-like Ileitis.Inflammatory bowel diseases · 2025Article
- Development and Initial Use of a New Inflammatory Bowel Disease Clinical Database Integrating Both Eastern and Western Clinical Characteristics.Chronic diseases and translational medicine · 2025Article
- Characteristics and Outcomes of Over a Million Patients with Inflammatory Bowel Disease in Seven Countries: Multinational Cohort Study and Open Data Resource.Digestive diseases and sciences · 2025Observational
- EPIDEMIOLOGICAL AND CLINICAL PROFILE OF CROHN'S DISEASE IN A BRAZILIAN REFERRAL CENTER IN 30 YEARS OF FOLLOW-UP.Arquivos de gastroenterologia · 2025Observational
- Association of early therapeutic drug monitoring of adalimumab with biologic remission and drug survival in Crohn's Disease.Therapeutic advances in gastroenterology · 2025Article
- Progression of Crohn's Disease in Newly Diagnosed Patients: Results from an Observational Study Using US Claims Data.Digestive diseases and sciences · 2024Observational
- Epidemiological investigation of different types of Crohn's disease patients undergoing first abdominal surgery in the era of biological agents: a population-based cohort study.International journal of colorectal disease · 2024Article
- Outcomes after right-sided colon surgery in Crohn's disease versus cancer.Techniques in coloproctology · 2024Article
- National 30-Day Readmission Trends in IBD 2014-2020-Are We Aiming for Improvement?Medicina (Kaunas, Lithuania) · 2024Article
- Postoperative outcomes of surgical delay in inflammatory bowel disease patients: a multicenter cohort study.Updates in surgery · 2024Article
- Development and validation of a scale to measure the care needs of Crohn's disease patients: a mixed-methods study.BMC nursing · 2024Article
- Positive resection margins in Crohn's disease are a relevant risk factor for postoperative disease recurrence.Scientific reports · 2024Article
- Fractal analysis of extracellular matrix for observer-independent quantification of intestinal fibrosis in Crohn's disease.Scientific reports · 2024Article
- Whither the coloproctologist of the future? Returning to the kindred spirit of the barber-surgeon.Techniques in coloproctology · 2024Article
- Mathematical Models Including microRNA Levels of Mesenteric Adipose Tissue May Predict Postoperative Relapse in Crohn's Disease Patients.Gastro hep advances · 2024Article
- The long-term effect on surgery-free survival of biological compared to conventional therapy in Crohn's disease in real world-data: a retrospective study.BMC gastroenterology · 2023Article
- Early Initiation of Adalimumab Significantly Diminishes Postoperative Crohn's Disease Endoscopic Recurrence and Is Superior to 6-Mercaptopurine Therapy: An Open-Label, Randomized Controlled Study.Journal of clinical medicine · 2023Article
- Temporal trends in surgery for Crohn's disease: a ten-year single-center retrospective study.International journal of colorectal disease · 2023Article
- Prophylactic Treatment with Vedolizumab in the Prevention of Postoperative Recurrence (POR) in High-Risk Crohn's Patients.Journal of clinical medicine · 2023Article
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeDespite primary conservative therapy for Crohn's disease, a considerable proportion of patients ultimately needs to undergo surgery. Presumably, due to the increased use of biologics, the number of surgeries might have decreased. This study aimed to delineate current case numbers and trends in surgery in the era of biological therapy for Crohn's disease.
methodsNationwide standardized hospital discharge data (diagnosis-related groups statistics) from 2010 to 2017 were used. All patients who were admitted as inpatient Crohn's disease cases in Germany were included. Time-related development of admission numbers, rate of surgery, morbidity, and mortality of inpatient Crohn's disease cases were analyzed.
resultsA total number of 201,165 Crohn's disease cases were included. Within the analyzed time period, the total number of hospital admissions increased by 10.6% (n = 23,301 vs. 26,069). While gender and age distribution remained comparable, patients with comorbidities such as stenosis formation (2010: 10.1%, 2017: 13.4%) or malnutrition (2010: 0.8%, 2017: 3.2%) were increasingly admitted. The total number of all analyzed operations for Crohn's disease increased by 7.5% (2010: n = 1567; 2017: n = 1694). On average, 6.8 ± 0.2% of all inpatient patients received ileocolonic resections. Procedures have increasingly been performed minimally invasive (2010: n = 353; 2017: n = 687). The number of postoperative complications remained low.
conclusionDespite the development of novel immunotherapeutics, the number of patients requiring surgery for Crohn's disease remains stable. Interestingly, patients have been increasingly hospitalized with stenosis and malnutrition. The trend towards more minimally invasive operations has not relevantly changed the rate of overall complications.
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