Evidence map›Paper›PMID 33876259›Full record

Trial reportEuropean journal of applied physiology2021

Ibuprofen taken before exercise blunts the IL-6 response in older adults but does not alter bone alkaline phosphatase or c-telopeptide.

Sarah J Wherry, Pamela Wolfe, Robert S Schwartz, Wendy M Kohrt, Catherine M Jankowski

2 registry-linked trialsOpen access · greenAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in European journal of applied physiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
0.6field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00462722 nacompletednot on this map

COX Inhibition & Musculoskeletal Responses to Exercise

TypeinterventionalSponsorUniversity of Colorado, DenverRan2007 to 2011Enrolled159ConditionsAging, Physical FitnessArmsIbuprofen, Placebo, musculoskeletal-loading exercise
NCT05512013 phase1completednot on this mapstarted 2022, after this paper: background citation

The Effects of Non-steroidal Anti-inflammatory Drugs on Circulating Markers of Bone Metabolism Following Plyometric Exercise in Humans

TypeinterventionalSponsorUnited States Army Research Institute of Environmental MedicineRan2022 to 2023Enrolled12ConditionsBone Resorption, Stress Fracture, Bone InjuryArmsIbuprofen 800 mg, Celecoxib 200mg, Flurbiprofen 100 mg, Placebo
3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it, 4 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Sarah J WherryDivision of Geriatric Medicine, Department of Medicine, University of Colorado Anschutz Medical Campus, Mail Stop B179, 12631 E. 17th Avenue, Room 8111, Aurora, CO, 80045, USA. sarah.wherry@cuanschutz.edu.ORCID http://orcid.org/0000-0001-8470-8847
Pamela WolfeDepartment of Preventive Medicine and Biostatistics, University of Colorado Anschutz Medical Campus, Mail Stop B179, 12631 E. 17th Avenue, Room 8111, Aurora, CO, 80045, USA.
Robert S SchwartzDivision of Geriatric Medicine, Department of Medicine, University of Colorado Anschutz Medical Campus, Mail Stop B179, 12631 E. 17th Avenue, Room 8111, Aurora, CO, 80045, USA.
Wendy M KohrtDivision of Geriatric Medicine, Department of Medicine, University of Colorado Anschutz Medical Campus, Mail Stop B179, 12631 E. 17th Avenue, Room 8111, Aurora, CO, 80045, USA.
Catherine M JankowskiDivision of Geriatric Medicine, Department of Medicine, University of Colorado Anschutz Medical Campus, Mail Stop B179, 12631 E. 17th Avenue, Room 8111, Aurora, CO, 80045, USA.
VA Eastern Colorado Health Care System · USUniversity of Colorado Anschutz Medical Campus · US

Funding

NIH Prior Approval Process ProfessionalUL1TR002535 · NCATS · UNIVERSITY OF COLORADO DENVER · PI SOKOL, RONALD J. · 2018 to 2022
$51.1M
PILOT STUDY--SUBSTRATE METABOLISM IN EXTREMELY LOW BIRTH WEIGHT INFANTSP30DK048520 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI Edward L Melanson · 1995 to 2026
$32.6M
Colorado Clinical and Translational Sciences Institute (CCTSI)UM1TR004399 · NCATS · UNIVERSITY OF COLORADO DENVER · PI JANINE A HIGGINS, RONALD J. SOKOL · 2023 to 2026
$30.7M
COX Inhibition & Musculoskeletal Responses to ExerciseR01AG018857 · NIA · UNIVERSITY OF COLORADO DENVER · PI KOHRT, WENDY M · 2000 to 2010
$4.0M
NCATS NIH HHS UL1 TR002535NCATS NIH HHS UM1 TR004399NIA NIH HHS R01 AG018857NIDDK NIH HHS P30 DK048520NIH HHS P30 DK048520NIH HHS UL1 TR002535
6 · The paper itself

Abstract

introductionNon-steroidal anti-inflammatory drugs (NSAIDs) taken before exercise have been shown to impair bone formation. NSAIDs also suppress inflammatory cytokines, such as interleukin-6 (IL-6), that can have pro-resorptive effects. It is unclear how taking NSAIDs timed around exercise influences inflammatory and bone biomarkers following an acute exercise bout in older adults. PURPOSE: To determine if timing of ibuprofen use relative to a single exercise bout has acute effects on serum IL-6, bone-specific alkaline phosphatase (BAP, marker of bone formation), and c-telopeptide of type I collagen (CTX, marker of bone resorption).

methodsAs part of a 36-week exercise intervention, participants aged 60 to 75 years were randomized to 3 groups: placebo before and after exercise (PP), ibuprofen before and placebo after exercise (IP), or placebo before and ibuprofen after exercise (PI). Acute responses were studied in a subset of participants (12 PP, 17 IP, 13 PI). Blood was sampled before and immediately, 30 min, and 60 min after exercise for IL-6, BAP, and CTX.

resultsThe exercise-induced increase in IL-6 was blunted in response to IP when compared to PI 60-min after exercise (p < 0.001). There were no significant differences in the change in BAP or CTX between groups at any time points

conclusionIbuprofen taken before exercise dampened the inflammatory response to exercise but had no effects on bone biomarkers in older adults. It may be necessary to monitor changes for a longer time interval after an acute exercise bout to determine whether bone turnover is altered by ibuprofen or other NSAIDs.

trial registrationClinicalTrials.gov: NCT00462722; Posted 04/19/2007.

Indexed as

ExerciseAgedAlkaline PhosphataseAnti-Inflammatory Agents, Non-SteroidalBiomarkersCollagen Type IFemaleHumansIbuprofenInterleukin-6MaleMiddle AgedPeptidesAlkaline PhosphataseAnti-Inflammatory Agents, Non-SteroidalBiomarkersCollagen Type Icollagen type I trimeric cross-linked peptideIbuprofenInterleukin-6PeptidesBone turnover markersExerciseNon-steroidal anti-inflammatory drugs

Identifiers

PMID33876259
PMCPMC11416062
OpenAlexW3154076459

What OpenQuestion holds

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Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.