ArticleEuropean heart journal2021
Sleep arousal burden is associated with long-term all-cause and cardiovascular mortality in 8001 community-dwelling older men and women.
Article in European heart journal, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers, 1 of them a synthesis that pooled it.
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The trial behind it
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Who cites it
57 citing papers in PubMed, 1 synthesis or guideline pooled it, 100 citations in OpenAlex.
- Association of alternative polysomnographic features with patient outcomes in obstructive sleep apnea: a systematic review.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2023Pooled it
- Trial
- Daily Exposure to Mild Intermittent Hypoxia Reduces Blood Pressure in Male Patients with Obstructive Sleep Apnea and Hypertension.American journal of respiratory and critical care medicine · 2022Trial
- Differential associations of arousals and respiratory events on oxygen desaturation and resaturation parameters in sleep.Sleep & breathing = Schlaf & Atmung · 2026Article
- Distinguishing Age-specific Patterns in Comorbidities of Obstructive Sleep Apnea Using Real-World Data.medRxiv : the preprint server for health sciences · 2026Article
- Delayed Arousal Response to Sleep Apnea Encodes Mortality.medRxiv : the preprint server for health sciences · 2026Article
- Asthma and Obstructive Sleep Apnea Overlap Syndrome Identifies a Phenotype of Sleep Instability and Increased Psychological Burden.Life (Basel, Switzerland) · 2026Article
- Cyclic alternating pattern in sleep electroencephalography as a novel predictor of dementia: A prospective study.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Cortical firing dynamics during micro-arousals vary with sleep/wake history and micro-arousal duration.Scientific reports · 2026Article
- Integrating phenotypic information of obstructive sleep apnea and deep representation of sleep-event sequences for cardiovascular risk prediction.BMC medical informatics and decision making · 2026Article
- Hypoxemia and arousals modulate cardiac responses to respiratory events in obstructive sleep apnea.Sleep · 2026Article
- A multimodal sleep foundation model for disease prediction.Nature medicine · 2026Article
- Tracking Cognitive Health With Wearables in Telerehabilitation Female Participants: Could Nighttime Sleep Measures Be Used as Sex-Specific Digital Endpoints?JMIR neurotechnology · 2026Article
- Impact of PMAnnals of medicine · 2025Article
- Characterisation of nocturnal arrhythmia avalanche dynamics: Insights from generalised linear model analysis.Journal of sleep research · 2025Article
- Tenascin-C and Thrombospondin-1 as a Potential Link Between Sleep Bruxism and Cardiovascular Diseases-A Case-Control Study.Journal of clinical medicine · 2025Article
- Sleep Temporal Entropy as a Novel Digital Biomarker of Sleep Fragmentation for Cardiometabolic and Mortality Risk.Research square · 2025Article
- Role of arousal in diagnosing sleep apnea in atrial fibrillation patients.Sleep & breathing = Schlaf & Atmung · 2025Article
- Clinical characteristics and outcomes of positional obstructive sleep apnea: the sleep heart health study.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2025Article
- Sleep Temporal Entropy as a Novel Digital Biomarker of Sleep Fragmentation for Cardiometabolic and Mortality Risk.medRxiv : the preprint server for health sciences · 2025Article
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Authors and funding
5 authors at 3 institutions in 4 countries.
Funding
Abstract
aimsTo quantify the arousal burden (AB) across large cohort studies and determine its association with long-term cardiovascular (CV) and overall mortality in men and women. METHODS AND
resultsWe measured the AB on overnight polysomnograms of 2782 men in the Osteoporotic Fractures in Men Study (MrOS) Sleep study, 424 women in the Study of Osteoporotic Fractures (SOF) and 2221 men and 2574 women in the Sleep Heart Health Study (SHHS). During 11.2 ± 2.1 years of follow-up in MrOS, 665 men died, including 236 CV deaths. During 6.4 ± 1.6 years of follow-up in SOF, 105 women died, including 47 CV deaths. During 10.7 ± 3.1 years of follow-up in SHHS, 987 participants died, including 344 CV deaths. In women, multivariable Cox proportional hazard analysis adjusted for common confounders demonstrated that AB is associated with all-cause mortality [SOF: hazard ratio (HR) 1.58 (1.01-2.42), P = 0.038; SHHS-women: HR 1.21 (1.06-1.42), P = 0.012] and CV mortality [SOF: HR 2.17 (1.04-4.50), P = 0.037; SHHS-women: HR 1.60 (1.12-2.28), P = 0.009]. In men, the association between AB and all-cause mortality [MrOS: HR 1.11 (0.94-1.32), P = 0.261; SHHS-men: HR 1.31 (1.06-1.62), P = 0.011] and CV mortality [MrOS: HR 1.35 (1.02-1.79), P = 0.034; SHHS-men: HR 1.24 (0.86-1.79), P = 0.271] was less clear.
conclusionsNocturnal AB is associated with long-term CV and all-cause mortality in women and to a lesser extent in men.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.