Evidence map›Paper›PMID 33876157›Full record

ArticleChemical communications (Cambridge, England)2021

The Hantzsch reaction for nitrogen-13 PET: preparation of [

Julia E Blower, Michelle T Ma, Fahad A I Al-Salemee, Antony D Gee

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chemical communications (Cambridge, England), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Julia E BlowerKing's College London, School of Biomedical Engineering and Imaging Sciences, Department of Imaging Chemistry and Biology, 4th Floor Lambeth Wing, St Thomas' Hospital, London, SE1 7EH, UK. julia.blower@kcl.ac.uk antony.gee@kcl.ac.uk.ORCID http://orcid.org/0000-0002-0350-3311
Michelle T MaKing's College London, School of Biomedical Engineering and Imaging Sciences, Department of Imaging Chemistry and Biology, 4th Floor Lambeth Wing, St Thomas' Hospital, London, SE1 7EH, UK. julia.blower@kcl.ac.uk antony.gee@kcl.ac.uk.ORCID http://orcid.org/0000-0002-3349-7346
Fahad A I Al-SalemeeKing's College London, School of Biomedical Engineering and Imaging Sciences, Department of Imaging Chemistry and Biology, 4th Floor Lambeth Wing, St Thomas' Hospital, London, SE1 7EH, UK. julia.blower@kcl.ac.uk antony.gee@kcl.ac.uk.ORCID http://orcid.org/0000-0001-5701-3783
Antony D GeeKing's College London, School of Biomedical Engineering and Imaging Sciences, Department of Imaging Chemistry and Biology, 4th Floor Lambeth Wing, St Thomas' Hospital, London, SE1 7EH, UK. julia.blower@kcl.ac.uk antony.gee@kcl.ac.uk.ORCID http://orcid.org/0000-0001-8389-9012

Funding

Cancer Research UK 24959Wellcome Trust
6 · The paper itself

Abstract

Nitrogen-13 is an attractive but under-used PET radionuclide for labelling molecules of biological and pharmaceutical interest, complementing other PET radionuclides. Its short half-life (t1/2 = 9.97 min) imposes synthetic challenges, but we have expanded the hitherto limited pool of 13N labelling strategies and tracers by adapting the multicomponent Hantzsch condensation reaction to prepare a library of 13N-labelled 1,4-dihydropyridines from [13N]ammonia, including the widely-used drug nifedipine. This represents a key advance in 13N PET radiochemistry, and will serve to underpin the renewed interest in clinical opportunities offered by short-lived PET tracers.

Identifiers

PMID33876157
PMCPMC8132178

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.