ArticleNature neuroscience2021
Attractor dynamics gate cortical information flow during decision-making.
Article in Nature neuroscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 76 papers.
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Who cites it
76 citing papers in PubMed, 141 citations in OpenAlex.
- Reusable modular architecture enables flexible cognitive operations in the mouse brain and artificial recurrent networks.Nature neuroscience · 2026Article
- A claustro-cortical loop times state transitions for flexible behavior.Research square · 2026Article
- A claustro-cortical loop times state transitions for flexible behavior.bioRxiv : the preprint server for biology · 2026Article
- Vulnerability of short-term memory in a mouse model of Alzheimer's disease.Nature communications · 2026Article
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- A biologically plausible decision-making model based on interacting neural populations.PloS one · 2026Article
- Cortical dopaminergic signaling mediates planning of directional movements.Science advances · 2025Article
- Neural dynamics outside task-coding dimensions drive decision trajectories through transient amplification.bioRxiv : the preprint server for biology · 2025Article
- Topological analysis of neuronal assemblies reveals low-rank structure modulated by cholinergic activity.bioRxiv : the preprint server for biology · 2025Article
- Article
- Nonlinear feedback modulation contributes to the optimization of flexible decision-making.eLife · 2025Article
- Neural dynamics of reversal learning in the prefrontal cortex and recurrent neural networks.eLife · 2025Article
- Reusable modular architecture enables flexible cognitive operations.Research square · 2025Article
- Short-term memory errors are strongly associated with a drift in neural activity in the posterior parietal cortex.PLoS biology · 2025Article
- Article
- Spatial reasoning via recurrent neural dynamics in mouse retrosplenial cortex.Nature neuroscience · 2025Article
- Neural mechanisms balancing accuracy and flexibility in working memory and decision tasks.NPJ systems biology and applications · 2025Article
- Mimicking opioid analgesia in cortical pain circuits.bioRxiv : the preprint server for biology · 2025Article
- Ramping dynamics in the frontal cortex unfold over multiple timescales during motor planning.Journal of neurophysiology · 2025Article
- Dynamical constraints on neural population activity.Nature neuroscience · 2025Article
16 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on by
- Erratum issued
Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Decisions are held in memory until enacted, which makes them potentially vulnerable to distracting sensory input. Gating of information flow from sensory to motor areas could protect memory from interference during decision-making, but the underlying network mechanisms are not understood. Here, we trained mice to detect optogenetic stimulation of the somatosensory cortex, with a delay separating sensation and action. During the delay, distracting stimuli lost influence on behavior over time, even though distractor-evoked neural activity percolated through the cortex without attenuation. Instead, choice-encoding activity in the motor cortex became progressively less sensitive to the impact of distractors. Reverse engineering of neural networks trained to reproduce motor cortex activity revealed that the reduction in sensitivity to distractors was caused by a growing separation in the neural activity space between attractors that encode alternative decisions. Our results show that communication between brain regions can be gated via attractor dynamics, which control the degree of commitment to an action.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.