ArticleNature materials2021
Integrated computer-aided engineering and design for DNA assemblies.
Article in Nature materials, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed.
- A computational framework for designing micron-scale crisscross DNA megastructures.Nature communications · 2026Article
- De novo design of DNA origami with a generative diffusion model.Nature communications · 2026Article
- In-Situ ssDNA Isolation from dsDNA Sources as a Streamlined Pathway to DNA Origami Assembly and Testing.bioRxiv : the preprint server for biology · 2026Article
- PyFuRNAce: an integrated design engine for RNA origami.Nature communications · 2025Article
- How We Simulate DNA Origami.Small methods · 2025Article
- Article
- Bioinspired designer DNA NanoGripper for virus sensing and potential inhibition.Science robotics · 2024Article
- 3D DNA origami pincers that multitask on giant unilamellar vesicles.Science advances · 2024Article
- Scalable computation of anisotropic vibrations for large macromolecular assemblies.Nature communications · 2024Article
- Mechanism of DNA origami folding elucidated by mesoscopic simulations.Nature communications · 2024Article
- DNA T-shaped crossover tiles for 2D tessellation and nanoring reconfiguration.Nature communications · 2023Article
- Mechanics of dynamic and deformable DNA nanostructures.Chemical science · 2023Review
- Versatile computer-aided design of free-form DNA nanostructures and assemblies.Science advances · 2023Article
- Evaluation of Nonmodified Wireframe DNA Origami for Acute Toxicity and Biodistribution in Mice.ACS applied bio materials · 2023Article
- Article
- Throwing and manipulating and cheating with a DNA nano-dice.Nature communications · 2023Article
- Evaluation of non-modified wireframe DNA origami for acute toxicity and biodistribution in mice.bioRxiv : the preprint server for biology · 2023Article
- Functionalizing DNA origami to investigate and interact with biological systems.Nature reviews. Materials · 2023Article
- Automated design of 3D DNA origami with non-rasterized 2D curvature.Science advances · 2022Article
- A label-free light-scattering method to resolve assembly and disassembly of DNA nanostructures.Biophysical journal · 2022Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Recently, DNA has been used to make nanodevices for a myriad of applications across fields including medicine, nanomanufacturing, synthetic biology, biosensing and biophysics. However, current DNA nanodevices rely primarily on geometric design, and it remains challenging to rationally design functional properties such as force-response or actuation behaviour. Here we report an iterative design pipeline for DNA assemblies that integrates computer-aided engineering based on coarse-grained molecular dynamics with a versatile computer-aided design approach that combines top-down automation with bottom-up control over geometry. This intuitive framework allows for rapid construction of large, multicomponent assemblies from three-dimensional models with finer control over the geometrical, mechanical and dynamical properties of the DNA structures in an automated manner. This approach expands the scope of structural complexity and enhances mechanical and dynamic design of DNA assemblies.
Indexed as
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.