ArticleMolecular psychiatry2021
Habitual coffee drinkers display a distinct pattern of brain functional connectivity.
Article in Molecular psychiatry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 1 of them a synthesis that pooled it.
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Who cites it
31 citing papers in PubMed, 1 synthesis or guideline pooled it, 75 citations in OpenAlex.
- Effects of caffeine on neuroinflammation in anxiety and depression: a systematic review of rodent studies.Translational psychiatry · 2025Pooled it
- Regular intake of caffeinated but not decaffeinated coffee attenuates behavioral modifications in mice subject to chronic unpredictable stress.Neurobiology of stress · 2026Article
- Feature overlap in transdiagnostic connectome-based models of sustained attention and autism symptoms.medRxiv : the preprint server for health sciences · 2026Article
- Habitual coffee intake shapes the gut microbiome and modifies host physiology and cognition.Nature communications · 2026Article
- The Effect of Caffeine Consumption and Acute Withdrawal on Resting-State fMRI Brain Connectivity, Mood and Cognition.The European journal of neuroscience · 2026Article
- Patterns of brain-wide associations reflect socioeconomics.bioRxiv : the preprint server for biology · 2025Article
- Upregulation of adenosine AMolecular psychiatry · 2025Article
- Review
- Functional connectivity and graph theory of impaired central visual pathways in acute ischemic stroke based on functional magnetic resonance imaging.Quantitative imaging in medicine and surgery · 2025Article
- Exploring the Impact and Mechanisms of Coffee and Its Active Ingredients on Depression, Anxiety, and Sleep Disorders.Nutrients · 2025Review
- Altered network efficiency in isolated REM sleep behavior disorder: A multicentric study.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Habitual caffeine intake, genetics and cognitive performance.Journal of psychopharmacology (Oxford, England) · 2025Article
- Longitudinal Effects of Lifetime Caffeine Consumption on Levels of Depression, Anxiety, and Stress: A Comprehensive Review.Current nutrition reports · 2025Review
- The relationship between work addiction and addictions to social media, shopping, food, caffeine, and nicotine.Australian journal of psychology · 2025Article
- Timing and dose matter: a diurnal pattern of coffee consumption optimises improvement in insulin resistance.Archives of medical science : AMS · 2025Article
- Examining recent effects of caffeine on default mode network and dorsal attention network anticorrelation in youth.PloS one · 2025Article
- Association between coffee consumption and metabolic syndrome: A cross-sectional and Mendelian randomization study.Journal of diabetes · 2024Article
- Genome-wide association studies of coffee intake in UK/US participants of European ancestry uncover cohort-specific genetic associations.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024Article
- Impact of Coffee Intake on Measures of Wellbeing in Mice.Nutrients · 2024Article
- plantMASST - Community-driven chemotaxonomic digitization of plants.bioRxiv : the preprint server for biology · 2024Article
Corrections and comments
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Authors and funding
12 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Coffee is the most widely consumed source of caffeine worldwide, partly due to the psychoactive effects of this methylxanthine. Interestingly, the effects of its chronic consumption on the brain's intrinsic functional networks are still largely unknown. This study provides the first extended characterization of the effects of chronic coffee consumption on human brain networks. Subjects were recruited and divided into two groups: habitual coffee drinkers (CD) and non-coffee drinkers (NCD). Resting-state functional magnetic resonance imaging (fMRI) was acquired in these volunteers who were also assessed regarding stress, anxiety, and depression scores. In the neuroimaging evaluation, the CD group showed decreased functional connectivity in the somatosensory and limbic networks during resting state as assessed with independent component analysis. The CD group also showed decreased functional connectivity in a network comprising subcortical and posterior brain regions associated with somatosensory, motor, and emotional processing as assessed with network-based statistics; moreover, CD displayed longer lifetime of a functional network involving subcortical regions, the visual network and the cerebellum. Importantly, all these differences were dependent on the frequency of caffeine consumption, and were reproduced after NCD drank coffee. CD showed higher stress levels than NCD, and although no other group effects were observed in this psychological assessment, increased frequency of caffeine consumption was also associated with increased anxiety in males. In conclusion, higher consumption of coffee and caffeinated products has an impact in brain functional connectivity at rest with implications in emotionality, alertness, and readiness to action.
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