ArticleJournal of perinatology : official journal of the California Perinatal Association2021
Relationship of patent ductus arteriosus management with neonatal AKI.
Article in Journal of perinatology : official journal of the California Perinatal Association, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 22 citations in OpenAlex.
- Trial
- Neonatal acute kidney injury and the patent ductus arteriosus.Pediatric nephrology (Berlin, Germany) · 2026Review
- Impact of transcatheter PDA closure on renal function in extremely low birth weight infants-a multicenter study.Journal of perinatology : official journal of the California Perinatal Association · 2026Article
- Understanding the Impact of Patent Ductus Arteriosus and Treatment Strategies on Acute Kidney Injury in Preterm Infants.American journal of perinatology · 2026Review
- Acute kidney injury in extremely preterm infants: findings from an Australian single-centre retrospective cohort study.Pediatric nephrology (Berlin, Germany) · 2026Article
- Clinical Impact of the PDA and Its Management on Outcomes of Preterm Infants with NEC: A Review.American journal of perinatology · 2026Review
- Stealing nephrons-a review on how patent ductus arteriosus physiology impacts neonatal kidney health.Journal of perinatology : official journal of the California Perinatal Association · 2026Review
- Prolonged patent ductus arteriosus exposure and risk for late acute kidney injury in extremely preterm infants.Journal of perinatology : official journal of the California Perinatal Association · 2026Article
- Employing a Haemodynamic Score to Predict Acute Kidney Injury in Infants With Patent Ductus Arteriosus.Acta paediatrica (Oslo, Norway : 1992) · 2025Article
- Neonatal Kidney Function, Injury and Drug Dosing: A Contemporary Review.Children (Basel, Switzerland) · 2025Review
- Advocating for the inclusion of kidney health outcomes in neonatal research: best practice recommendations by the Neonatal Kidney Collaborative.Journal of perinatology : official journal of the California Perinatal Association · 2024Review
- Indomethacin patent ductus arteriosus prophylaxis in the modern era: renal implications.Journal of perinatology : official journal of the California Perinatal Association · 2023Article
- Neonatal acute kidney injury during indomethacin therapy: does it predict ductal closure?Journal of nephrology · 2023Article
- Costs associated with acute kidney injury in critically Ill neonates with patent Ductus arteriosus: pediatric health information system (PHIS) analysis.Journal of perinatology : official journal of the California Perinatal Association · 2022Article
- When the progresses in neonatology lead to severe congenital nephron deficit: is there a pilot in the NICU?Pediatric nephrology (Berlin, Germany) · 2022Article
- Neonatal AKI in late preterm infants with patent ductus arteriosus.Journal of perinatology : official journal of the California Perinatal Association · 2021Article
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Authors and funding
7 authors at 20 institutions in 3 countries.
Funding
Abstract
objectiveInvestigate relationship between management of patent ductus arteriosus (PDA) and acute kidney injury (AKI) in very low birthweight neonates. STUDY
designRetrospective cohort study of neonates, <1500 g, admitted to 24 NICUs, 1/1/14 - 3/31/14. AKI diagnosed using the neonatal modified KDIGO definition; diagnosis and treatment of PDA extracted from the medical record. Demographics, clinical characteristics, and AKI stage compared using chi-square and analysis of variance. A general estimating equation logistic regression used to estimate adjusted odds ratios.
resultsOf 526 neonates with sufficient data to diagnose AKI, 157 (30%) had PDA (61 conservative management, 62 pharmacologic treatment only, 34 surgical ligation). In analyses adjusted for sex, birthweight, gestational age, caffeine, nephrotoxin exposure, vasopressor and mechanical ventilation use, with conservative management as reference, there were no differences among treatment cohorts in the odds of AKI.
conclusionThe underlying physiology of PDA, not management strategy, may determine the likelihood of AKI in neonates <1500 g.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.