Evidence map›Paper›PMID 33875739›Full record

ArticleScientific reports2021

Image-based personalization of computational models for predicting response of high-grade glioma to chemoradiation.

David A Hormuth, Karine A Al Feghali, Andrew M Elliott, Thomas E Yankeelov, Caroline Chung

Abstract read
In one paragraph

Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.

0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

40 citing papers in PubMed.

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  11. Inverse Problem Regularization for 3D Multi-Species Tumor Growth Models.International journal for numerical methods in biomedical engineering · 2025
    Article
  12. Article
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  14. Identifiability and model selection frameworks for models of high-grade glioma response to chemoradiation.Philosophical transactions. Series A, Mathematical, physical, and engineering sciences · 2025
    Article
  15. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

David A HormuthOden Institute for Computational Engineering and Sciences, The University of Texas at Austin, Austin, 201 E. 24th Street, POB 4.102, 1 University Station (C0200), Austin, TX, 78712-1229, USA. david.hormuth@utexas.edu.
Karine A Al FeghaliDepartment of Radiation Oncology, MD Anderson Cancer Center, Houston, TX, USA.
Andrew M ElliottDepartment of Radiation Oncology, MD Anderson Cancer Center, Houston, TX, USA.
Thomas E YankeelovOden Institute for Computational Engineering and Sciences, The University of Texas at Austin, Austin, 201 E. 24th Street, POB 4.102, 1 University Station (C0200), Austin, TX, 78712-1229, USA.
Caroline ChungDepartment of Radiation Oncology, MD Anderson Cancer Center, Houston, TX, USA.

Funding

INTEGRATING OMICS AND QUANTITATIVE IMAGING DATA IN CO-CLINICAL TRIALS TO PREDICT TREATMENT RESPONSE IN TRIPLE NEGATIVE BREAST CANCERU24CA226110 · NCI · BAYLOR COLLEGE OF MEDICINE · PI LEWIS, MICHAEL T., RUBIN, DANIEL L · 2019 to 2023
$3.2M
Clinical Development of Rhenium Nanoliposomes (RNL186) for GlioblastomaR01CA235800 · NCI · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI BRENNER, ANDREW JACOB · 2019 to 2023
$3.0M
Image Driven Multi-Scale Modeling to Predict Treatment Response in Breast CancerU01CA174706 · NCI · VANDERBILT UNIVERSITY · PI QUARANTA, VITO, YANKEELOV, THOMAS E · 2013 to 2018
$2.5M
Fellow and Resident Radiation Oncology iNtensive Training in Imaging and Informatics to Empower Research Careers (FRONTI2ER)R25EB025787 · NIBIB · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI DAS, PRAJNAN, FULLER, CLIFTON DAVID · 2018 to 2022
$535k
NCI NIH HHS R01 CA235800NCI NIH HHS U01 CA174706NCI NIH HHS U24 CA226110NIBIB NIH HHS R25 EB025787
6 · The paper itself

Abstract

High-grade gliomas are an aggressive and invasive malignancy which are susceptible to treatment resistance due to heterogeneity in intratumoral properties such as cell proliferation and density and perfusion. Non-invasive imaging approaches can measure these properties, which can then be used to calibrate patient-specific mathematical models of tumor growth and response. We employed multiparametric magnetic resonance imaging (MRI) to identify tumor extent (via contrast-enhanced T

Indexed as

AgedBrain NeoplasmsChemoradiotherapyComputer SimulationDiffusion Magnetic Resonance ImagingFemaleGliomaHumansMagnetic Resonance ImagingMaleMiddle AgedMultiparametric Magnetic Resonance Imaging

Identifiers

PMID33875739
PMCPMC8055874

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.