Evidence map›Paper›PMID 33875641›Full record

ArticleTranslational psychiatry2021

Do environmental risk factors for the development of psychosis distribute differently across dimensionally assessed psychotic experiences?

Jan Cosgrave, Ross J Purple, Ross Haines, Kate Porcheret, Dalena van Heugten-van der Kloet, Louise Johns, Iona Alexander, Guy M Goodwin, Russell G Foster, Katharina Wulff

Open access · goldAbstract read
In one paragraph

Article in Translational psychiatry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.8field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 16 citations in OpenAlex.

  1. Observational
  2. Article
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  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 7 institutions in 4 countries.

Jan CosgraveSleep and Circadian Neuroscience Institute, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK. jan.cosgrave@ndcn.ox.ac.uk.ORCID 0000-0002-1150-2423
Ross J PurpleDepartment of Physiology, Pharmacology and Neuroscience, University of Bristol, Biomedical Sciences Building, University Walk, Bristol, UK.ORCID 0000-0003-1061-8106
Ross HainesDepartment of Statistics, University of Oxford, South Parks Road, Oxford, UK.
Kate PorcheretNorwegian Centre for Violence & Traumatic Stress Studies, University of Oslo, Oslo, Norway.
Dalena van Heugten-van der KloetDepartment of Clinical Psychological Science, Maastricht University, Maastricht University, Maastricht, The Netherlands.ORCID 0000-0002-3404-1279
Louise JohnsDepartment of Psychiatry, University of Oxford, Warneford Hospital, Oxford, UK.ORCID 0000-0003-3355-3202
Iona AlexanderSleep and Circadian Neuroscience Institute, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK.ORCID 0000-0002-1021-5887
Guy M GoodwinDepartment of Psychiatry, University of Oxford, Warneford Hospital, Oxford, UK.ORCID 0000-0002-1426-2816
Russell G FosterSleep and Circadian Neuroscience Institute, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK.ORCID 0000-0001-6055-2067
Katharina WulffDepartments of Radiation Sciences and Molecular Biology, Umeå University, Umeå, Sweden.ORCID 0000-0003-2480-3329
University of Oxford · GBNational Health Service · GBDepartment of Health and Social Care · GBMaastricht University · NLUmeå University · SEUniversity of Bristol · GBUniversity of Oslo · NO

Funding

DH | National Institute for Health Research (NIHR) A90305DH | National Institute for Health Research (NIHR) HQR00960Wellcome Trust
6 · The paper itself

Abstract

Psychotic experiences (PE) are associated with poorer functioning, higher distress and the onset of serious mental illness. Environmental exposures (e.g. childhood abuse) are associated with the development of PE. However, which specific exposures convey risk for each type or dimension of PE has rarely been explored. The Oxford Wellbeing Life and Sleep (OWLS) survey includes 22 environmental risk factors for psychosis and was designed to examine how environmental risks are associated with specific dimensions of PE. Multivariate logistic regression models were fit using these risk factors to predict six dimensions of PE (perceptual abnormalities, persecutory ideation, bizarre ideas, cognitive disorganisation, delusional mood and negative symptoms). Models were built using only 70% of the data, and then fit to the remaining data to assess their generalisability and quality. 1789 (27.2% men; mean age = 27.6; SD = 10.9) survey responses were analysed. The risk factors predictive of the most PE were anxiety, social withdrawal during childhood and trauma. Cannabis and depression predicted three dimensions with both predicting bizarre ideas and persecutory ideation. Psychological abuse and sleep quality each predicted two dimensions (persecutory ideation and delusional mood). Risk factors predicting one PE dimension were age (predicting cognitive disorganisation), physical abuse (bizarre ideas), bullying and gender (persecutory ideation); and circadian phase (delusional mood). These results lend support for a continuum of psychosis, suggesting environmental risks for psychotic disorders also increase the risk of assorted dimensions of PE. Furthermore, it advocates the use of dimensional approaches when examining environmental exposures for PE given that environmental risks distribute differently across dimensions.

Indexed as

Psychotic DisordersAnxietyAnxiety DisordersChildHumansInterpersonal RelationsRisk Factors

Identifiers

PMID33875641
PMCPMC8055691
OpenAlexW3152991695

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.