Evidence map›Paper›PMID 33875635›Full record

ArticleSignal transduction and targeted therapy2021

SAHA attenuates Takotsubo-like myocardial injury by targeting an epigenetic Ac/Dc axis.

Ishant Khurana, Scott Maxwell, Simon Royce, Prabhu Mathiyalagan, Tom Karagiannis, Nadia Mazarakis, Jitraporn Vongsvivut, Harikrishnan K N, Jun Okabe, Keith Al-Hasani and 2 more

Abstract readLetter
In one paragraph

Article in Signal transduction and targeted therapy, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Genetic and Epigenetic Factors of Takotsubo Syndrome: A Systematic Review.International journal of molecular sciences · 2021
    Pooled it
  2. A Genome-Wide Association Study of Takotsubo Syndrome.JACC. Basic to translational science · 2026
    Article
  3. Review
  4. Article
  5. Article
  6. Review
  7. Mitochondrial epigenetics in aging and cardiovascular diseases.Frontiers in cardiovascular medicine · 2023
    Review
  8. "Obesity paradox" and takotsubo syndrome.International journal of cardiology. Cardiovascular risk and prevention · 2022
    Review
  9. Article
  10. Inhibition of pancreatic EZH2 restores progenitor insulin in T1D donor.Signal transduction and targeted therapy · 2022
    Article
  11. Review
  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Ishant Khurana *Human Epigenetics Program, Department of Diabetes, Central Clinical School, Monash University, Melbourne, VIC, Australia.ORCID 0000-0001-9050-2749
Scott Maxwell *Human Epigenetics Program, Department of Diabetes, Central Clinical School, Monash University, Melbourne, VIC, Australia.ORCID 0000-0002-7801-0714
Simon Royce *Cardiovascular Disease Program, Monash Biomedicine Discovery Institute and Department of Pharmacology, Monash University, Clayton, VIC, Australia.ORCID 0000-0001-5841-1775
Prabhu MathiyalaganHuman Epigenetics Program, Department of Diabetes, Central Clinical School, Monash University, Melbourne, VIC, Australia.ORCID 0000-0002-8202-9266
Tom KaragiannisHuman Epigenetics Program, Department of Diabetes, Central Clinical School, Monash University, Melbourne, VIC, Australia.ORCID 0000-0002-9967-1546
Nadia MazarakisHuman Epigenetics Program, Department of Diabetes, Central Clinical School, Monash University, Melbourne, VIC, Australia.ORCID 0000-0001-7681-2775
Jitraporn VongsvivutInfrared Microspectroscopy Beamline, ANSTO - Australian Synchrotron, Clayton, VIC, Australia.ORCID 0000-0003-0699-3464
Harikrishnan K NHuman Epigenetics Program, Department of Diabetes, Central Clinical School, Monash University, Melbourne, VIC, Australia.ORCID 0000-0002-4662-659X
Jun OkabeHuman Epigenetics Program, Department of Diabetes, Central Clinical School, Monash University, Melbourne, VIC, Australia.ORCID 0000-0002-7196-0522
Keith Al-HasaniHuman Epigenetics Program, Department of Diabetes, Central Clinical School, Monash University, Melbourne, VIC, Australia.ORCID 0000-0001-6109-5603
Chrishan SamuelCardiovascular Disease Program, Monash Biomedicine Discovery Institute and Department of Pharmacology, Monash University, Clayton, VIC, Australia.ORCID 0000-0003-0295-4214
Assam El-OstaHuman Epigenetics Program, Department of Diabetes, Central Clinical School, Monash University, Melbourne, VIC, Australia. sam.el-osta@monash.edu.ORCID 0000-0001-7968-7375

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Takotsubo CardiomyopathyAcetylationAnimalsDisease Models, AnimalEpigenesis, GeneticMiceVorinostatVorinostat

Identifiers

PMID33875635
PMCPMC8055670

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.